Mutation of the alpha 2 domain disulfide bridge of the class I molecule HLA-A*0201. Effect on maturation and peptide presentation.

A combination of saturation and site-directed mutagenesis was utilized to disrupt the alpha 2 domain disulfide bridge of HLA-A*0201. Mutation of cysteine 101 to a serine (C101S) or of cysteine 164 to alanine (C164A) decreased the rate of maturation of the heavy chain, the total amount of mature heav...

Descrizione completa

Dettagli Bibliografici
Autori principali: Warburton, R, Matsui, M, Rowland-Jones, S, Gammon, M, Katzenstein, G, Wei, T, Edidin, M, Zweerink, H, Mcmichael, A, Frelinger, J
Natura: Journal article
Lingua:English
Pubblicazione: 1994