Mutation of the alpha 2 domain disulfide bridge of the class I molecule HLA-A*0201. Effect on maturation and peptide presentation.

Mutation of the alpha 2 domain disulfide bridge of the class I molecule HLA-A*0201. Effect on maturation and peptide presentation.

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A combination of saturation and site-directed mutagenesis was utilized to disrupt the alpha 2 domain disulfide bridge of HLA-A*0201. Mutation of cysteine 101 to a serine (C101S) or of cysteine 164 to alanine (C164A) decreased the rate of maturation of the heavy chain, the total amount of mature heav...

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Bibliographic Details
Main Authors:	Warburton, R, Matsui, M, Rowland-Jones, S, Gammon, M, Katzenstein, G, Wei, T, Edidin, M, Zweerink, H, Mcmichael, A, Frelinger, J
Format:	Journal article
Language:	English
Published:	1994

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