Structural insights into the binding of cardiac glycosides to the digitalis receptor revealed by solid-state NMR.

Structural insights into the binding of cardiac glycosides to the digitalis receptor revealed by solid-state NMR.

Several biologically active derivatives of the cardiotonic steroid ouabain have been made containing NMR isotopes ((13)C, (2)H, and (19)F) in the rhamnose sugar and steroid moieties, and examined at the digitalis receptor site of renal Na(+)/K(+)-ATPase by a combination of solid-state NMR methods. D...

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Autori principali:	Middleton, D, Rankin, S, Esmann, M, Watts, A
Natura:	Journal article
Lingua:	English
Pubblicazione:	2000

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