Population genomic scan for candidate signatures of balancing selection to guide antigen characterization in malaria parasites

Population genomic scan for candidate signatures of balancing selection to guide antigen characterization in malaria parasites

Acquired immunity in vertebrates maintains polymorphisms in endemic pathogens, leading to identifiable signatures of balancing selection. To comprehensively survey for genes under such selection in the human malaria parasite Plasmodium falciparum, we generated paired-end short-read sequences of para...

Full beskrivning

Bibliografiska uppgifter
Huvudupphovsmän:	Amambua-Ngwa, A, Tetteh, K, Manske, M, Gomez-Escobar, N, Stewart, L, Deerhake, M, Cheeseman, I, Newbold, C, Holder, A, Knuepfer, E, Janha, O, Jallow, M, Campino, S, Macinnis, B, Kwiatkowski, D, Conway, D
Materialtyp:	Journal article
Språk:	English
Publicerad:	Public Library of Science 2012

Liknande verk

Population genomic scan for candidate signatures of balancing selection to guide antigen characterization in malaria parasites.
av: Alfred Amambua-Ngwa, et al.
Publicerad: (2012-01-01)

Prospective identification of malaria parasite genes under balancing selection.
av: Tetteh, K, et al.
Publicerad: (2009)

Studies of natural selection on malaria parasite merozoites in relation to invasion and immunity.
av: Tetteh, K, et al.
Publicerad: (2008)

Genome-wide analysis of selection on the malaria parasite Plasmodium falciparum in West African populations of differing infection endemicity.
av: Mobegi, V, et al.
Publicerad: (2014)

Prospective identification of malaria parasite genes under balancing selection.
av: Kevin K A Tetteh, et al.
Publicerad: (2009-01-01)

Changes in malaria parasite drug resistance in an endemic population over a 25-year period with resulting genomic evidence of selection.
av: Nwakanma, D, et al.
Publicerad: (2014)

Multi-population genomic analysis of malaria parasites indicates local selection and differentiation at the gdv1 locus regulating sexual development
av: Duffy, C, et al.
Publicerad: (2018)

Multiplication rate variation in the human malaria parasite Plasmodium falciparum
av: Lee Murray, et al.
Publicerad: (2017-07-01)

Multiplication rate variation of malaria parasites from hospital cases and community infections
av: Lindsay B. Stewart, et al.
Publicerad: (2025-01-01)

Publisher Correction: Multiplication rate variation of malaria parasites from hospital cases and community infections
av: Lindsay B. Stewart, et al.
Publicerad: (2025-02-01)

SnoopCGH: software for visualizing comparative genomic hybridization data.
av: Almagro-Garcia, J, et al.
Publicerad: (2009)

SnoopCGH: software for visualizing comparative genomic hybridization data.
av: Almagro-Garcia, J, et al.
Publicerad: (2009)

Optimizing Illumina next-generation sequencing library preparation for extremely AT-biased genomes.
av: Oyola, S, et al.
Publicerad: (2012)

Optimized Whole-Genome Amplification Strategy for Extremely AT-Biased Template.
av: Oyola, S, et al.
Publicerad: (2014)

Highly Variable Expression of Merozoite Surface Protein MSPDBL2 in Diverse Plasmodium falciparum Clinical Isolates and Transcriptome Scans for Correlating Genes
av: Suzanne E. Hocking, et al.
Publicerad: (2022-08-01)

Culture adaptation of malaria parasites selects for convergent loss-of-function mutants
av: Kwiatkowski, D, et al.
Publicerad: (2017)

Investigation of host candidate malaria-associated risk/protective SNPs in a Brazilian Amazonian population.
av: da Silva Santos, S, et al.
Publicerad: (2012)

Statistical estimation of cell-cycle progression and lineage commitment in Plasmodium falciparum reveals a homogeneous pattern of transcription in ex vivo culture.
av: Lemieux, J, et al.
Publicerad: (2009)

Deletion of Plasmodium falciparum ubc13 increases parasite sensitivity to the mutagen, methyl methanesulfonate and dihydroartemisinin
av: Supawadee Maneekesorn, et al.
Publicerad: (2021-11-01)

Efficient depletion of host DNA contamination in malaria clinical sequencing.
av: Oyola, S, et al.
Publicerad: (2013)

Genetic disruption of Plasmodium falciparum Merozoite surface antigen 180 (PfMSA180) suggests an essential role during parasite egress from erythrocytes
av: Vanndita Bahl, et al.
Publicerad: (2021-09-01)

An effective method to purify Plasmodium falciparum DNA directly from clinical blood samples for whole genome high-throughput sequencing
av: Auburn, S, et al.
Publicerad: (2011)

Monitoring parasite diversity for malaria elimination in sub-Saharan Africa.
av: Ghansah, A, et al.
Publicerad: (2014)

Consistent signatures of selection from genomic analysis of pairs of temporal and spatial Plasmodium falciparum populations from The Gambia
av: Amambua-Ngwa, A, et al.
Publicerad: (2018)

Drug-resistant genotypes and multi-clonality in Plasmodium falciparum analysed by direct genome sequencing from peripheral blood of malaria patients
av: Robinson, T, et al.
Publicerad: (2011)

Drug-resistant genotypes and multi-clonality in Plasmodium falciparum analysed by direct genome sequencing from peripheral blood of malaria patients
av: Robinson, T, et al.
Publicerad: (2011)

Stepwise in vitro screening of MMV pathogen box compounds against Plasmodium falciparum to identify potent antimalarial candidates
av: Haddijatou Mbye, et al.
Publicerad: (2023-08-01)

Host candidate gene polymorphisms and clearance of drug-resistant Plasmodium falciparum parasites.
av: Diakite, M, et al.
Publicerad: (2011)

Genome-wide screen identifies new candidate genes associated with artemisinin susceptibility in Plasmodium falciparum in Kenya
av: Borrmann, S, et al.
Publicerad: (2013)

SNP-o-matic.
av: Manske, H, et al.
Publicerad: (2009)

A transcriptional switch underlies commitment to sexual development in malaria parasites.
av: Kafsack, B, et al.
Publicerad: (2014)

Micro-epidemiological structuring of Plasmodium falciparum parasite populations in regions with varying transmission intensities in Africa
av: Omedo, I, et al.
Publicerad: (2017)

Characterization of within-host Plasmodium falciparum diversity using next-generation sequence data.
av: Auburn, S, et al.
Publicerad: (2012)

PB2502: PREVALENCE AND ANTIMICROBIAL SUSCEPTIBILITY PATTERN OF BACTERIAL PATHOGENS ISOLATED FROM SICKLE CELL PATIENTS ADMITTED AT MRCG WARD FROM 2015 TO 2022
av: Alfred Amambua-Ngwa, et al.
Publicerad: (2023-08-01)

Long read assemblies of geographically dispersed Plasmodium falciparum isolates reveal highly structured subtelomeres
av: Otto, TD, et al.
Publicerad: (2018)

Plasmodium malariae and ovale genomes provide insights into malaria parasite evolution
av: Newbold, C, et al.
Publicerad: (2017)

Whole-genome scans provide evidence of adaptive evolution in Malawian Plasmodium falciparum isolates.
av: Ocholla, H, et al.
Publicerad: (2014)

Laboratory indices of hospitalized sickle cell disease patients, prevalence and antimicrobial susceptibility of pathogenic bacterial isolates at MRCG ward in the Gambia
av: Mustapha Dibbasey, et al.
Publicerad: (2023-08-01)

An optimized microarray platform for assaying genomic variation in Plasmodium falciparum field populations
av: Tan, J, et al.
Publicerad: (2011)

Population genetic structure and adaptation of malaria parasites on the edge of endemic distribution
av: Duffy, C, et al.
Publicerad: (2017)