Drug resistance. Population transcriptomics of human malaria parasites reveals the mechanism of artemisinin resistance.

Drug resistance. Population transcriptomics of human malaria parasites reveals the mechanism of artemisinin resistance.

Artemisinin resistance in Plasmodium falciparum threatens global efforts to control and eliminate malaria. Polymorphisms in the kelch domain-carrying protein K13 are associated with artemisinin resistance, but the underlying molecular mechanisms are unknown. We analyzed the in vivo transcriptomes of...

Cur síos iomlán

Sonraí bibleagrafaíochta
Príomhchruthaitheoirí:	Mok, S, Ashley, E, Ferreira, P, Zhu, L, Lin, Z, Yeo, T, Chotivanich, K, Imwong, M, Pukrittayakamee, S, Dhorda, M, Nguon, C, Lim, P, Amaratunga, C, Suon, S, Hien, T, Htut, Y, Faiz, M, Onyamboko, M, Mayxay, M, Newton, P, Tripura, R, Woodrow, C, Miotto, O, Kwiatkowski, D, Nosten, F
Formáid:	Journal article
Teanga:	English
Foilsithe / Cruthaithe:	2015

Míreanna comhchosúla

Population transcriptomics of human malaria parasites reveals the mechanism of artemisinin resistance
de réir: Mok, S., et al.
Foilsithe / Cruthaithe: (2016)

Spread of artemisinin resistance in Plasmodium falciparum malaria.
de réir: Ashley, E, et al.
Foilsithe / Cruthaithe: (2014)

Genetic architecture of artemisinin-resistant Plasmodium falciparum
de réir: Miotto, O, et al.
Foilsithe / Cruthaithe: (2015)

Host immunity and the assessment of emerging artemisinin resistance in a multinational cohort
de réir: Ataide, R, et al.
Foilsithe / Cruthaithe: (2017)

The mechanism of artemisinin resistance of Plasmodium falciparum malaria parasites originates in their initial transcriptional response
de réir: Zhu, L, et al.
Foilsithe / Cruthaithe: (2021)

Artemisinin resistance in the malaria parasite, Plasmodium falciparum, originates from its initial transcriptional response
de réir: Zhu, L, et al.
Foilsithe / Cruthaithe: (2022)

Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia.
de réir: Miotto, O, et al.
Foilsithe / Cruthaithe: (2013)

Analysis of anti-malarial resistance markers in pfmdr1 and pfcrt across Southeast Asia in the Tracking Resistance to Artemisinin Collaboration
de réir: Srimuang, K, et al.
Foilsithe / Cruthaithe: (2016)

Laboratory detection of artemisinin-resistant Plasmodium falciparum.
de réir: Chotivanich, K, et al.
Foilsithe / Cruthaithe: (2014)

Exploring the contribution of candidate genes to artemisinin resistance in Plasmodium falciparum.
de réir: Imwong, M, et al.
Foilsithe / Cruthaithe: (2010)

Artemisinin resistance in Plasmodium falciparum is associated with an altered temporal pattern of transcription.
de réir: Mok, S, et al.
Foilsithe / Cruthaithe: (2011)

Comparison of antibody responses and parasite clearance in artemisinin therapeutic efficacy studies in Democratic Republic of Congo and Asia
de réir: Cutts, JC, et al.
Foilsithe / Cruthaithe: (2022)

Artemisinin resistance and malaria elimination: Where are we now?
de réir: Borimas Hanboonkunupakarn, et al.
Foilsithe / Cruthaithe: (2022-09-01)

Analysis of anti-malarial resistance markers in pfmdr1 and pfcrt across Southeast Asia in the Tracking Resistance to Artemisinin Collaboration
de réir: Krongkan Srimuang, et al.
Foilsithe / Cruthaithe: (2016-11-01)

Spread of artemisinin resistance in plasmodium falciparum malaria
de réir: Tripura, Rupam, et al.
Foilsithe / Cruthaithe: (2015)

Correction to: Analysis of anti-malarial resistance markers in pfmdr1 and pfcrt across Southeast Asia in the Tracking Resistance to Artemisinin Collaboration
de réir: Krongkan Srimuang, et al.
Foilsithe / Cruthaithe: (2018-09-01)

Artemisinin resistance without pfkelch13 mutations in Plasmodium falciparum isolates from Cambodia.
de réir: Mukherjee, A, et al.
Foilsithe / Cruthaithe: (2017)

The spread of artemisinin-resistant Plasmodium falciparum in the Greater Mekong Subregion: a molecular epidemiology observational study
de réir: Imwong, M, et al.
Foilsithe / Cruthaithe: (2017)

Effect of high-dose or split-dose artesunate on parasite clearance in artemisinin-resistant falciparum malaria.
de réir: Das, D, et al.
Foilsithe / Cruthaithe: (2013)

Artemisinin resistance in the malaria parasite, Plasmodium falciparum, originates from its initial transcriptional response
de réir: Zhu, Lei, et al.
Foilsithe / Cruthaithe: (2022)

Artemisinin resistance in the malaria parasite, Plasmodium falciparum, originates from its initial transcriptional response
de réir: Lei Zhu, et al.
Foilsithe / Cruthaithe: (2022-03-01)

Artemisinin resistance and malaria elimination: where are we now?
de réir: Hanboonkunupakarn, B, et al.
Foilsithe / Cruthaithe: (2022)

The contribution of functional antimalarial immunity to measures of parasite clearance in therapeutic efficacy studies of artemisinin derivatives
de réir: O'Flaherty, K, et al.
Foilsithe / Cruthaithe: (2019)

Artemisinin resistance and stage dependency of parasite clearance in Falciparum malaria
de réir: Intharabut, B, et al.
Foilsithe / Cruthaithe: (2019)

Assessment in vitro of the antimalarial and transmission-blocking activities of cipargamin and ganaplacide in artemisinin-resistant Plasmodium falciparum
de réir: Yipsirimetee, A, et al.
Foilsithe / Cruthaithe: (2022)

Artemisinin resistance in Plasmodium falciparum malaria.
de réir: Dondorp, A, et al.
Foilsithe / Cruthaithe: (2009)

Genomic epidemiology of artemisinin resistant malaria.
de réir: MalariaGEN Plasmodium falciparum Community Project, et al.
Foilsithe / Cruthaithe: (2016)

Parasite clearance rates in Upper Myanmar indicate a distinctive artemisinin resistance phenotype: a therapeutic efficacy study.
de réir: Smithuis, F, et al.
Foilsithe / Cruthaithe: (2016)

Optimal health and disease management using spatial uncertainty: a geographic characterization of emergent artemisinin-resistant Plasmodium falciparum distributions in Southeast Asia
de réir: Grist, E, et al.
Foilsithe / Cruthaithe: (2016)

Triple therapy with artemether-lumefantrine plus amodiaquine versus artemether-lumefantrine alone for artemisinin-resistant, uncomplicated falciparum malaria: an open-label, randomised, multicentre trial
de réir: Peto, TJ, et al.
Foilsithe / Cruthaithe: (2022)

Artemisinin resistance in <it>Plasmodium falciparum </it>is associated with an altered temporal pattern of transcription
de réir: Newton Paul N, et al.
Foilsithe / Cruthaithe: (2011-08-01)

Preventing antimalarial drug resistance with triple artemisinin-based combination therapies
de réir: Nguyen, TD, et al.
Foilsithe / Cruthaithe: (2023)

A major genome region underlying artemisinin resistance in malaria.
de réir: Cheeseman, I, et al.
Foilsithe / Cruthaithe: (2012)

Independent emergence of artemisinin resistance mutations among Plasmodium falciparum in Southeast Asia.
de réir: Takala-Harrison, S, et al.
Foilsithe / Cruthaithe: (2015)

A major genome region underlying artemisinin resistance in malaria.
de réir: Cheeseman, I, et al.
Foilsithe / Cruthaithe: (2012)

A molecular marker of artemisinin-resistant Plasmodium falciparum malaria.
de réir: Ariey, F, et al.
Foilsithe / Cruthaithe: (2014)

A molecular marker of artemisinin-resistant Plasmodium falciparum malaria
de réir: Ariey, F, et al.
Foilsithe / Cruthaithe: (2014)

The origins of malaria artemisinin resistance defined by a genetic and transcriptomic background
de réir: Zhu, Lei, et al.
Foilsithe / Cruthaithe: (2019)

Mechanisms of artemisinin action and resistance: wider focus is needed.
de réir: Woodrow, C, et al.
Foilsithe / Cruthaithe: (2011)

No evidence for spread of Plasmodium falciparum artemisinin resistance to Savannakhet Province, Southern Laos.
de réir: Mayxay, M, et al.
Foilsithe / Cruthaithe: (2012)