Drug resistance. Population transcriptomics of human malaria parasites reveals the mechanism of artemisinin resistance.

Drug resistance. Population transcriptomics of human malaria parasites reveals the mechanism of artemisinin resistance.

Artemisinin resistance in Plasmodium falciparum threatens global efforts to control and eliminate malaria. Polymorphisms in the kelch domain-carrying protein K13 are associated with artemisinin resistance, but the underlying molecular mechanisms are unknown. We analyzed the in vivo transcriptomes of...

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Détails bibliographiques
Auteurs principaux: Mok, S, Ashley, E, Ferreira, P, Zhu, L, Lin, Z, Yeo, T, Chotivanich, K, Imwong, M, Pukrittayakamee, S, Dhorda, M, Nguon, C, Lim, P, Amaratunga, C, Suon, S, Hien, T, Htut, Y, Faiz, M, Onyamboko, M, Mayxay, M, Newton, P, Tripura, R, Woodrow, C, Miotto, O, Kwiatkowski, D, Nosten, F
Format: Journal article
Langue:English
Publié: 2015

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