The impact of viral mutations on recognition by SARS-CoV-2 specific T-cells

The impact of viral mutations on recognition by SARS-CoV-2 specific T-cells

We identify amino acid variants within dominant SARS-CoV-2 T cell epitopes by interrogating global sequence data. Several variants within nucleocapsid and ORF3a epitopes have arisen independently in multiple lineages and result in loss of recognition by epitope-specific T cells assessed by IFN-γ and...

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Bibliographic Details
Main Authors: de Silva, TI, Liu, G, Lindsey, BB, Dong, D, Moore, SC, Hsu, NS, Shah, D, Wellington, D, Mentzer, AJ, Angyal, A, Brown, R, Parker, MD, Ying, Z, Yao, X, Turtle, L, Dunachie, S, Maini, MK, Ogg, G, Knight, JC, Peng, Y, Rowland-Jones, SL, Dong, T
Format: Journal article
Language:English
Published: Cell Press 2021

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