Diazepam alters brain 5-HT function in man: implications for the acute and chronic effects of benzodiazepines.
The effect of diazepam on brain 5-HT-mediated neuroendocrine responses was studied in healthy male volunteers. An acute dose of diazepam (15 mg) significantly attenuated the prolactin and growth hormone responses to intravenous L-tryptophan. After 3 weeks administration of diazepam (25 mg/d) these r...
| 主要な著者: | , |
|---|---|
| フォーマット: | Journal article |
| 言語: | English |
| 出版事項: |
1987
|
| _version_ | 1826272966854311936 |
|---|---|
| author | Nutt, D Cowen, P |
| author_facet | Nutt, D Cowen, P |
| author_sort | Nutt, D |
| collection | OXFORD |
| description | The effect of diazepam on brain 5-HT-mediated neuroendocrine responses was studied in healthy male volunteers. An acute dose of diazepam (15 mg) significantly attenuated the prolactin and growth hormone responses to intravenous L-tryptophan. After 3 weeks administration of diazepam (25 mg/d) these responses had returned to normal despite much higher plasma diazepam concentrations, suggesting that tolerance had occurred. A reduction in brain 5-HT function may underlie some of the acute therapeutic actions of benzodiazepines. It is possible that excessive 'rebound' 5-HT activity may contribute to the abstinence syndrome seen on benzodiazepine withdrawal. |
| first_indexed | 2024-03-06T22:20:54Z |
| format | Journal article |
| id | oxford-uuid:5505f22e-fe66-4e70-890e-1e1d2e3b3f1f |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:20:54Z |
| publishDate | 1987 |
| record_format | dspace |
| spelling | oxford-uuid:5505f22e-fe66-4e70-890e-1e1d2e3b3f1f2022-03-26T16:41:26ZDiazepam alters brain 5-HT function in man: implications for the acute and chronic effects of benzodiazepines.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:5505f22e-fe66-4e70-890e-1e1d2e3b3f1fEnglishSymplectic Elements at Oxford1987Nutt, DCowen, PThe effect of diazepam on brain 5-HT-mediated neuroendocrine responses was studied in healthy male volunteers. An acute dose of diazepam (15 mg) significantly attenuated the prolactin and growth hormone responses to intravenous L-tryptophan. After 3 weeks administration of diazepam (25 mg/d) these responses had returned to normal despite much higher plasma diazepam concentrations, suggesting that tolerance had occurred. A reduction in brain 5-HT function may underlie some of the acute therapeutic actions of benzodiazepines. It is possible that excessive 'rebound' 5-HT activity may contribute to the abstinence syndrome seen on benzodiazepine withdrawal. |
| spellingShingle | Nutt, D Cowen, P Diazepam alters brain 5-HT function in man: implications for the acute and chronic effects of benzodiazepines. |
| title | Diazepam alters brain 5-HT function in man: implications for the acute and chronic effects of benzodiazepines. |
| title_full | Diazepam alters brain 5-HT function in man: implications for the acute and chronic effects of benzodiazepines. |
| title_fullStr | Diazepam alters brain 5-HT function in man: implications for the acute and chronic effects of benzodiazepines. |
| title_full_unstemmed | Diazepam alters brain 5-HT function in man: implications for the acute and chronic effects of benzodiazepines. |
| title_short | Diazepam alters brain 5-HT function in man: implications for the acute and chronic effects of benzodiazepines. |
| title_sort | diazepam alters brain 5 ht function in man implications for the acute and chronic effects of benzodiazepines |
| work_keys_str_mv | AT nuttd diazepamaltersbrain5htfunctioninmanimplicationsfortheacuteandchroniceffectsofbenzodiazepines AT cowenp diazepamaltersbrain5htfunctioninmanimplicationsfortheacuteandchroniceffectsofbenzodiazepines |