Structural characterization of melatonin as an inhibitor of the Wnt deacylase Notum
The hormone melatonin, secreted from the pineal gland, mediates multiple physiological effects including modulation of Wnt/β-catenin signalling. The Wnt palmitoleate lipid modification is essential for its signalling activity, while the carboxylesterase Notum can remove the lipid from Wnt...
Main Authors: | Zhao, Y, Ren, J, Hillier, J, Jones, M, Lu, W, Jones, EY |
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Format: | Journal article |
Language: | English |
Published: |
Wiley
2020
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