Human DNA polymerases lambda and beta show different efficiencies of translesion DNA synthesis past abasic sites and alternative mechanisms for frameshift generation.

Human DNA polymerases lambda and beta show different efficiencies of translesion DNA synthesis past abasic sites and alternative mechanisms for frameshift generation.

Human DNA polymerases (pols) beta and lambda could promote template slippage and generate -1 frameshifts on defined heteropolymeric DNA substrates containing a single abasic site. Kinetic data demonstrated that pol lambda was more efficient than pol beta in catalyzing translesion DNA synthesis past...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς:	Blanca, G, Villani, G, Shevelev, I, Ramadan, K, Spadari, S, Hübscher, U, Maga, G
Μορφή:	Journal article
Γλώσσα:	English
Έκδοση:	2004

Παρόμοια τεκμήρια

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DNA elongation by the human DNA polymerase lambda polymerase and terminal transferase activities are differentially coordinated by proliferating cell nuclear antigen and replication protein A.
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DNA polymerase lambda from calf thymus preferentially replicates damaged DNA.
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Structural insight into recruitment of translesion DNA polymerase Dpo4 to sliding clamp PCNA.
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The TREX2 3′→ 5′ Exonuclease Physically Interacts with DNA Polymerase δ and Increases Its Accuracy
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Polymerase exchange on single DNA molecules reveals processivity clamp control of translesion synthesis
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Translesion synthesis and error-prone polymerases.
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Overexpression of DNA polymerase beta results in an increased rate of frameshift mutations during base excision repair.
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Correction: The translesion DNA polymerases Pol ζ and Rev1 are activated independently of PCNA ubiquitination upon UV radiation in mutants of DNA polymerase δ.
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Effect of a Monofunctional Phenanthriplatin-DNA Adduct on RNA Polymerase II Transcriptional Fidelity and Translesion Synthesis
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