Human DNA polymerases lambda and beta show different efficiencies of translesion DNA synthesis past abasic sites and alternative mechanisms for frameshift generation.

Human DNA polymerases lambda and beta show different efficiencies of translesion DNA synthesis past abasic sites and alternative mechanisms for frameshift generation.

Human DNA polymerases (pols) beta and lambda could promote template slippage and generate -1 frameshifts on defined heteropolymeric DNA substrates containing a single abasic site. Kinetic data demonstrated that pol lambda was more efficient than pol beta in catalyzing translesion DNA synthesis past...

书目详细资料
Main Authors:	Blanca, G, Villani, G, Shevelev, I, Ramadan, K, Spadari, S, Hübscher, U, Maga, G
格式:	Journal article
语言:	English
出版:	2004

相似书籍

Human DNA polymerase lambda functionally and physically interacts with proliferating cell nuclear antigen in normal and translesion DNA synthesis.
由: Maga, G, et al.
出版: (2002)

Human DNA polymerase lambda diverged in evolution from DNA polymerase beta toward specific Mn(++) dependence: a kinetic and thermodynamic study.
由: Blanca, G, et al.
出版: (2003)

Mutagenesis of human DNA polymerase lambda: essential roles of Tyr505 and Phe506 for both DNA polymerase and terminal transferase activities.
由: Shevelev, I, et al.
出版: (2003)

De novo DNA synthesis by human DNA polymerase lambda, DNA polymerase mu and terminal deoxyribonucleotidyl transferase.
由: Ramadan, K, et al.
出版: (2004)

DNA elongation by the human DNA polymerase lambda polymerase and terminal transferase activities are differentially coordinated by proliferating cell nuclear antigen and replication protein A.
由: Maga, G, et al.
出版: (2005)

DNA polymerase lambda from calf thymus preferentially replicates damaged DNA.
由: Ramadan, K, et al.
出版: (2002)

The human DNA polymerase lambda interacts with PCNA through a domain important for DNA primer binding and the interaction is inhibited by p21/WAF1/CIP1.
由: Maga, G, et al.
出版: (2004)

Gap-directed translesion DNA synthesis of an abasic site on circular DNA templates by a human replication complex.
由: Giuseppe Villani, et al.
出版: (2014-01-01)

Human DNA polymerase lambda possesses terminal deoxyribonucleotidyl transferase activity and can elongate RNA primers: implications for novel functions.
由: Ramadan, K, et al.
出版: (2003)

DNA polymerase theta purified from human cells is a high-fidelity enzyme.
由: Maga, G, et al.
出版: (2002)

DNA polymerases and diseases
由: Ramadan, K, et al.
出版: (2007)

Inhibition of mammalian DNA polymerases by resveratrol: mechanism and structural determinants.
由: Locatelli, G, et al.
出版: (2005)

The DNA-polymerase-X family: controllers of DNA quality?
由: Ramadan, K, et al.
出版: (2004)

Repair of abasic sites in DNA.
由: Dianov, G, et al.
出版: (2003)

Regulation of translesion synthesis DNA polymerase eta by monoubiquitination.
由: Bienko, M, et al.
出版: (2010)

Biological relevance of DNA polymerase beta and translesion synthesis polymerases to cancer and its treatment
由: Nicolay, N, et al.
出版: (2012)

Distinctive roles of translesion polymerases DinB1 and DnaE2 in diversification of the mycobacterial genome through substitution and frameshift mutagenesis
由: Pierre Dupuy, et al.
出版: (2022-08-01)

Role of Translesion Synthesis DNA Polymerases in DNA Replication in the Presence of a Weak DNA Polymerase δ in Saccharomyces cerevisiae
由: Likui Zhang, et al.
出版: (2018-02-01)

Biological relevance of DNA polymerase β and translesion synthesis polymerases to cancer and its treatment.
由: Nicolay, N, et al.
出版: (2012)

The TREX2 3'-->5' exonuclease physically interacts with DNA polymerase delta and increases its accuracy.
由: Shevelev, I, et al.
出版: (2002)

Structural insight into recruitment of translesion DNA polymerase Dpo4 to sliding clamp PCNA.
由: Xing, G, et al.
出版: (2009)

The TREX2 3′→ 5′ Exonuclease Physically Interacts with DNA Polymerase δ and Increases Its Accuracy
由: Igor V. Shevelev, et al.
出版: (2002-01-01)

Division of labor of Y-family polymerases in translesion-DNA synthesis for distinct types of DNA damage.
由: Yuriko Inomata, et al.
出版: (2021-01-01)

Proteasomal regulation of the mutagenic translesion DNA polymerase, Saccharomyces cerevisiae Rev1
由: Wiltrout, Mary Ellen, et al.
出版: (2015)

SCREENING OF ONCOGENIC VARIANTS IN DNA POLYMERASES WITH TRANSLESION SYNTHESIS ACTIVITY IN MYELODYSPLASTIC NEOPLASM
由: RTG Oliveira, et al.
出版: (2023-10-01)

Translesion polymerase kappa-dependent DNA synthesis underlies replication fork recovery
由: Peter Tonzi, et al.
出版: (2018-11-01)

A comprehensive strategy to discover inhibitors of the translesion synthesis DNA polymerase κ.
由: Kinrin Yamanaka, et al.
出版: (2012-01-01)

Polymerase exchange on single DNA molecules reveals processivity clamp control of translesion synthesis
由: Kath, James E., et al.
出版: (2014)

Contributions of replicative and translesion DNA polymerases to mutagenic bypass of canonical and atypical UV photoproducts
由: Brittany N. Vandenberg, et al.
出版: (2023-05-01)

Architecture of Y-Family DNA Polymerases Relevant to Translesion DNA Synthesis as Revealed in Structural and Molecular Modeling Studies
由: Sushil Chandani, et al.
出版: (2010-01-01)

Structural basis for the recognition and cleavage of abasic DNA in Neisseria meningitidis.
由: Lu, D, et al.
出版: (2012)

The translesion DNA polymerases Pol ζ and Rev1 are activated independently of PCNA ubiquitination upon UV radiation in mutants of DNA polymerase δ.
由: Carine Tellier-Lebegue, et al.
出版: (2017-12-01)

Single-molecule imaging reveals multiple pathways for the recruitment of translesion polymerases after DNA damage
由: Elizabeth S. Thrall, et al.
出版: (2017-12-01)

Cryo-EM structure of translesion DNA synthesis polymerase ζ with a base pair mismatch
由: Radhika Malik, et al.
出版: (2022-02-01)

Translesion synthesis: Y-family polymerases and the polymerase switch.
由: Lehmann, A, et al.
出版: (2007)

Translesion synthesis and error-prone polymerases.
由: Green, C, et al.
出版: (2005)

Overexpression of DNA polymerase beta results in an increased rate of frameshift mutations during base excision repair.
由: Chan, K, et al.
出版: (2007)

Correction: The translesion DNA polymerases Pol ζ and Rev1 are activated independently of PCNA ubiquitination upon UV radiation in mutants of DNA polymerase δ.
由: Carine Tellier-Lebegue, et al.
出版: (2018-02-01)

Translesion DNA synthesis in the context of cancer research
由: Knobel Philip A, et al.
出版: (2011-11-01)

Effect of a Monofunctional Phenanthriplatin-DNA Adduct on RNA Polymerase II Transcriptional Fidelity and Translesion Synthesis
由: Kellinger, Matthew W., et al.
出版: (2014)