Glial biology in learning and cognition.
Neurons are exquisitely specialized for rapid electrical transmission of signals, but some properties of glial cells, which do not communicate with electrical impulses, are well suited for participating in complex cognitive functions requiring broad spatial integration and long-term temporal regulat...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
SAGE Publications
2014
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| _version_ | 1797069223389822976 |
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| author | Fields, R Araque, A Johansen-Berg, H Lim, S Lynch, G Nave, K Nedergaard, M Perez, R Sejnowski, T Wake, H |
| author_facet | Fields, R Araque, A Johansen-Berg, H Lim, S Lynch, G Nave, K Nedergaard, M Perez, R Sejnowski, T Wake, H |
| author_sort | Fields, R |
| collection | OXFORD |
| description | Neurons are exquisitely specialized for rapid electrical transmission of signals, but some properties of glial cells, which do not communicate with electrical impulses, are well suited for participating in complex cognitive functions requiring broad spatial integration and long-term temporal regulation. Astrocytes, microglia, and oligodendrocytes all have biological properties that could influence learning and cognition. Myelination by oligodendrocytes increases conduction velocity, affecting spike timing and oscillations in neuronal activity. Astrocytes can modulate synaptic transmission and may couple multiple neurons and synapses into functional assemblies. Microglia can remove synapses in an activity-dependent manner altering neural networks. Incorporating glia into a bicellular mechanism of nervous system function may help answer long-standing questions concerning the cellular mechanisms of learning and cognition. |
| first_indexed | 2024-03-06T22:21:17Z |
| format | Journal article |
| id | oxford-uuid:55246ab0-6b53-4ab2-83fc-96b9332cbe3e |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:21:17Z |
| publishDate | 2014 |
| publisher | SAGE Publications |
| record_format | dspace |
| spelling | oxford-uuid:55246ab0-6b53-4ab2-83fc-96b9332cbe3e2022-03-26T16:42:07ZGlial biology in learning and cognition.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:55246ab0-6b53-4ab2-83fc-96b9332cbe3eEnglishSymplectic Elements at OxfordSAGE Publications2014Fields, RAraque, AJohansen-Berg, HLim, SLynch, GNave, KNedergaard, MPerez, RSejnowski, TWake, HNeurons are exquisitely specialized for rapid electrical transmission of signals, but some properties of glial cells, which do not communicate with electrical impulses, are well suited for participating in complex cognitive functions requiring broad spatial integration and long-term temporal regulation. Astrocytes, microglia, and oligodendrocytes all have biological properties that could influence learning and cognition. Myelination by oligodendrocytes increases conduction velocity, affecting spike timing and oscillations in neuronal activity. Astrocytes can modulate synaptic transmission and may couple multiple neurons and synapses into functional assemblies. Microglia can remove synapses in an activity-dependent manner altering neural networks. Incorporating glia into a bicellular mechanism of nervous system function may help answer long-standing questions concerning the cellular mechanisms of learning and cognition. |
| spellingShingle | Fields, R Araque, A Johansen-Berg, H Lim, S Lynch, G Nave, K Nedergaard, M Perez, R Sejnowski, T Wake, H Glial biology in learning and cognition. |
| title | Glial biology in learning and cognition. |
| title_full | Glial biology in learning and cognition. |
| title_fullStr | Glial biology in learning and cognition. |
| title_full_unstemmed | Glial biology in learning and cognition. |
| title_short | Glial biology in learning and cognition. |
| title_sort | glial biology in learning and cognition |
| work_keys_str_mv | AT fieldsr glialbiologyinlearningandcognition AT araquea glialbiologyinlearningandcognition AT johansenbergh glialbiologyinlearningandcognition AT lims glialbiologyinlearningandcognition AT lynchg glialbiologyinlearningandcognition AT navek glialbiologyinlearningandcognition AT nedergaardm glialbiologyinlearningandcognition AT perezr glialbiologyinlearningandcognition AT sejnowskit glialbiologyinlearningandcognition AT wakeh glialbiologyinlearningandcognition |