RNA helicase DDX1 converts RNA G-quadruplex structures into R-Loops to promote IgH class switch recombination
Class switch recombination (CSR) at the immunoglobulin heavy-chain (IgH) locus is associated with the formation of R-loop structures over switch (S) regions. While these often occur co-transcriptionally between nascent RNA and template DNA, we now show that they also form as part of a post-transcrip...
Main Authors: | Ribeiro de Almeida, C, Dhir, S, Dhir, A, Moghaddam, A, Sattentau, Q, Meinhart, A, Proudfoot, N |
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Format: | Journal article |
Language: | English |
Published: |
ScienceDirect
2018
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