A Novel Haplotype on GCH1 Gene, Encoding GTP Cyclohydrolase 1, Regulates Vascular Biopterin Synthesis, eNOS Coupling and Vascular Redox in Human Vessels

Bibliografiset tiedot
Päätekijät:	Antoniades, C, Shirodaria, C, Guzik, T, Van-Assche, T, Pillai, R, Lotsch, J, Tousoulis, D, Stefanadis, C, Tegeder, I, Channon, K
Aineistotyyppi:	Conference item
Julkaistu:	2008

Genetic variation in GCH1, encoding GTP-cyclohydrolase 1, regulates biopterin levels and endothelial function in atherosclerosis
Tekijä: Van, A, et al.
Julkaistu: (2008)

GCH1 haplotype determines vascular and plasma biopterin availability in coronary artery disease effects on vascular superoxide production and endothelial function.
Tekijä: Antoniades, C, et al.
Julkaistu: (2008)

Clinical genetics of functionally mild non-coding GTP cyclohydrolase 1 (GCH1) polymorphisms modulating pain and cardiovascular risk.
Tekijä: Doehring, A, et al.
Julkaistu: (2008)

Rapid Effects of Atorvastatin on Tetrahydrobiopterin-Mediated eNOS Coupling in Human Arteries, is Mediated by Stimulation of Vascular GTP-Cyclohydrolase
Tekijä: Antoniades, C, et al.
Julkaistu: (2011)

Polymorphism of MTHFR gene affects vascular redox and nitric oxide bioavailability by modifying eNOS coupling
Tekijä: Antoniades, C, et al.
Julkaistu: (2008)

Regulation of β-adrenergic control of heart rate by GTP-cyclohydrolase 1 (GCH1) and tetrahydrobiopterin.
Tekijä: Adlam, D, et al.
Julkaistu: (2012)

Regulation of β-adrenergic control of heart rate by GTP-cyclohydrolase 1 (GCH1) and tetrahydrobiopterin
Tekijä: Adlam, D, et al.
Julkaistu: (2012)

Genetic variability of MTHFR affects vascular redox and nitric oxide bioavailability in human vessels, by modifying eNOS coupling
Tekijä: Antoniades, C, et al.
Julkaistu: (2008)

Plasma asymmetrical-dimethyl-arginine affects eNOS vascular superoxide radical production and nitric oxide bioavailability in human arteries and veins
Tekijä: Antoniades, C, et al.
Julkaistu: (2008)

Lack of influence of GTP cyclohydrolase gene (<it>GCH1</it>) variations on pain sensitivity in humans
Tekijä: Dionne Raymond A, et al.
Julkaistu: (2007-03-01)

Induction of vascular GTP-cyclohydrolase I and endogenous tetrahydrobiopterin synthesis protect against inflammation-induced endothelial dysfunction in human atherosclerosis.
Tekijä: Antoniades, C, et al.
Julkaistu: (2011)

Induction of vascular GTP-cyclohydrolase i and endogenous tetrahydrobiopterin synthesis protect against inflammation-induced endothelial dysfunction in human atherosclerosis
Tekijä: Antoniades, C, et al.
Julkaistu: (2011)

Haplotype on GTP-Cyclohydrolase I Gene, Reveals a Novel Role of Tetrahydrobiopterin as a Defense Mechanism Against Inflammation-Induced Endothelial Dysfunction in Human Atherosclerosis
Tekijä: Antoniades, C, et al.
Julkaistu: (2011)

Relationships between vascular/plasma biopterins and endothelial nitric oxide synthase coupling, endothelial function and inflammation, in human atherosclerosis
Tekijä: Antoniades, C, et al.
Julkaistu: (2008)

Altered plasma vs. vascular biopterins in human atherosclerosis reveal relationships between endothelial nitric oxide synthase coupling, endothelial function and inflammation
Tekijä: Antomades, C, et al.
Julkaistu: (2007)

Quantitative regulation of intracellular endothelial nitric-oxide synthase (eNOS) coupling by both tetrahydrobiopterin-eNOS stoichiometry and biopterin redox status: insights from cells with tet-regulated GTP cyclohydrolase I expression.
Tekijä: Crabtree, M, et al.
Julkaistu: (2009)

Altered plasma versus vascular biopterins in human atherosclerosis reveal relationships between endothelial nitric oxide synthase coupling, endothelial function, and inflammation.
Tekijä: Antoniades, C, et al.
Julkaistu: (2007)

Genetic Polymorphism On Methyl-Tetrahydrofolate-Reductase Affects Vascular Superoxide Generation and Nitric Oxide Bioavailability By Regulating eNOS Coupling in Human Arteries and Veins
Tekijä: Antoniades, C, et al.
Julkaistu: (2009)

Generation of an iPSC line from a patient with GTP cyclohydrolase 1 (GCH1) deficiency: HDMC0061i-GCH1
Tekijä: Sabine Jung-Klawitter, et al.
Julkaistu: (2017-04-01)

Genetic Variability of Methyl-Tetrahydrofolate-Reductase Modifies eNOS Coupling in Human Arteries and Veins: Effects on Vascular Superoxide Generation and Nitric Oxide Bioavailabllity
Tekijä: Antoniades, C, et al.
Julkaistu: (2008)

Plasma levels of sCD40-ligand interact with homocysteine biosynthetic pathway and predict eNOS coupling in human vessels: effects on vascular redox state
Tekijä: Antoniades, C, et al.
Julkaistu: (2008)

Soluble CD40-ligand levels are associated with vascular superoxide production and eNOS coupling in human vessels: Interrelationships with homocysteine biosynthetic pathway
Tekijä: Antoniades, C, et al.
Julkaistu: (2008)

Endothelial-targeted GTP cyclohydrolase I overexpression increases endothelial tetrahydrobiopterin levels and preserves eNOS coupling in eNOS overexpressing mice
Tekijä: Bendall, J, et al.
Julkaistu: (2004)

CHRONIC ORAL TETRAHYDROBIOPTERIN TREATMENT IN PATIENTS WITH CORONARY ARTERY DISEASE ELEVATES TOTAL BIOPTERIN LEVELS BUT DOES NOT IMPROVE BIOPTERIN REDOX STATUS OR VASCULAR FUNCTION: A RANDOMISED PLACEBO-CONTROLLED TRIAL
Tekijä: Cunnington, C, et al.
Julkaistu: (2010)

Vascular Homocysteine Versus 5-Methyl-Tetrahydrofolate As Regulators of Vascular Redox and Endothelial Function in Human Vessels
Tekijä: Antoniades, C, et al.
Julkaistu: (2009)

The common genetic polymorphism C677T of methyltetrahydrofolate reductase regulates nitric oxide bioavailability and vascular superoxide production via modulation of eNOS coupling in human vessels
Tekijä: Antoniades, C, et al.
Julkaistu: (2007)

Tetrahydrobiopterin- and glutathionylation-dependent regulation of eNOS coupling: Relationships revealed by eNOS glutathionylation mutants in cells with tet-regulated GTP cyclohydrolase I expression
Tekijä: Crabtree, M, et al.
Julkaistu: (2012)

GTP cyclohydrolase I expression, protein, and activity determine intracellular tetrahydrobiopterin levels, independent of GTP cyclohydrolase feedback regulatory protein expression.
Tekijä: Tatham, A, et al.
Julkaistu: (2009)

Plasma asymmetrical-dimethyl-arginine (ADMA) as a regulator of vascular redox and nitric oxide bioavailability in human vessels
Tekijä: Antoniades, C, et al.
Julkaistu: (2007)

Parkinson's disease in GTP cyclohydrolase 1 mutation carriers.
Tekijä: Ryan, B, et al.
Julkaistu: (2014)

Chronic oral tetrahydrobiopterin therapy in coronary artery disease elevates total biopterin levels but does not improve redox status or vascular function: a randomized placebo-controlled trial
Tekijä: Cunnington, C, et al.
Julkaistu: (2010)

Relationships between nitric oxide-mediated endothelial function, eNOS coupling and blood pressure revealed by eNOS-GTP cyclohydrolase 1 double transgenic mice.
Tekijä: Adlam, D, et al.
Julkaistu: (2007)

GTP cyclohydrolase II structure and mechanism.
Tekijä: Ren, J, et al.
Julkaistu: (2005)

Atorvastatin directly improves vascular redox state by affecting eNOS coupling and NADPH-oxidase activity in human vein grafts ex-vivo
Tekijä: Bakogiannis, C, et al.
Julkaistu: (2010)

Stoichiometric relationships between endothelial tetrahydrobiopterin, endothelial NO synthase (eNOS) activity, and eNOS coupling in vivo: insights from transgenic mice with endothelial-targeted GTP cyclohydrolase 1 and eNOS overexpression.
Tekijä: Bendall, J, et al.
Julkaistu: (2005)

Vascular Homocysteine vs 5-Methyl-Tetrahydrofolate as Regulators of Vascular Redox and Endothelial Function in Human Vessels
Tekijä: Antoniades, C, et al.
Julkaistu: (2008)

Does the pain-protective GTP cyclohydrolase haplotype significantly alter the pattern or severity of pain in humans with chronic pancreatitis?
Tekijä: Anderson Michelle A, et al.
Julkaistu: (2008-11-01)

Nitric oxide Bioavailability is preserved in diabetes by increased endothelial tetrahydrobiopterin synthesis in targeted GTP cyclohydrolase transgenic mice
Tekijä: Alp, N, et al.
Julkaistu: (2003)

GTP cyclohydrolase I deficiency results in oxidative stress and pulmonary hypertension
Tekijä: Khoo, J, et al.
Julkaistu: (2004)

Association of plasma asymmetrical dimethylarginine (ADMA) with elevated vascular superoxide production and endothelial nitric oxide synthase uncoupling: implications for endothelial function in human atherosclerosis.
Tekijä: Antoniades, C, et al.
Julkaistu: (2009)

A Novel Haplotype on GCH1 Gene, Encoding GTP Cyclohydrolase 1, Regulates Vascular Biopterin Synthesis, eNOS Coupling and Vascular Redox in Human Vessels

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