A Novel Haplotype on GCH1 Gene, Encoding GTP Cyclohydrolase 1, Regulates Vascular Biopterin Synthesis, eNOS Coupling and Vascular Redox in Human Vessels

書誌詳細
主要な著者:	Antoniades, C, Shirodaria, C, Guzik, T, Van-Assche, T, Pillai, R, Lotsch, J, Tousoulis, D, Stefanadis, C, Tegeder, I, Channon, K
フォーマット:	Conference item
出版事項:	2008

Genetic variation in GCH1, encoding GTP-cyclohydrolase 1, regulates biopterin levels and endothelial function in atherosclerosis
著者:: Van, A, 等
出版事項: (2008)

GCH1 haplotype determines vascular and plasma biopterin availability in coronary artery disease effects on vascular superoxide production and endothelial function.
著者:: Antoniades, C, 等
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Clinical genetics of functionally mild non-coding GTP cyclohydrolase 1 (GCH1) polymorphisms modulating pain and cardiovascular risk.
著者:: Doehring, A, 等
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Rapid Effects of Atorvastatin on Tetrahydrobiopterin-Mediated eNOS Coupling in Human Arteries, is Mediated by Stimulation of Vascular GTP-Cyclohydrolase
著者:: Antoniades, C, 等
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Polymorphism of MTHFR gene affects vascular redox and nitric oxide bioavailability by modifying eNOS coupling
著者:: Antoniades, C, 等
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Regulation of β-adrenergic control of heart rate by GTP-cyclohydrolase 1 (GCH1) and tetrahydrobiopterin.
著者:: Adlam, D, 等
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Regulation of β-adrenergic control of heart rate by GTP-cyclohydrolase 1 (GCH1) and tetrahydrobiopterin
著者:: Adlam, D, 等
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Genetic variability of MTHFR affects vascular redox and nitric oxide bioavailability in human vessels, by modifying eNOS coupling
著者:: Antoniades, C, 等
出版事項: (2008)

Plasma asymmetrical-dimethyl-arginine affects eNOS vascular superoxide radical production and nitric oxide bioavailability in human arteries and veins
著者:: Antoniades, C, 等
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Lack of influence of GTP cyclohydrolase gene (<it>GCH1</it>) variations on pain sensitivity in humans
著者:: Dionne Raymond A, 等
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Induction of vascular GTP-cyclohydrolase I and endogenous tetrahydrobiopterin synthesis protect against inflammation-induced endothelial dysfunction in human atherosclerosis.
著者:: Antoniades, C, 等
出版事項: (2011)

Induction of vascular GTP-cyclohydrolase i and endogenous tetrahydrobiopterin synthesis protect against inflammation-induced endothelial dysfunction in human atherosclerosis
著者:: Antoniades, C, 等
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Haplotype on GTP-Cyclohydrolase I Gene, Reveals a Novel Role of Tetrahydrobiopterin as a Defense Mechanism Against Inflammation-Induced Endothelial Dysfunction in Human Atherosclerosis
著者:: Antoniades, C, 等
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Relationships between vascular/plasma biopterins and endothelial nitric oxide synthase coupling, endothelial function and inflammation, in human atherosclerosis
著者:: Antoniades, C, 等
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Altered plasma vs. vascular biopterins in human atherosclerosis reveal relationships between endothelial nitric oxide synthase coupling, endothelial function and inflammation
著者:: Antomades, C, 等
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Quantitative regulation of intracellular endothelial nitric-oxide synthase (eNOS) coupling by both tetrahydrobiopterin-eNOS stoichiometry and biopterin redox status: insights from cells with tet-regulated GTP cyclohydrolase I expression.
著者:: Crabtree, M, 等
出版事項: (2009)

Altered plasma versus vascular biopterins in human atherosclerosis reveal relationships between endothelial nitric oxide synthase coupling, endothelial function, and inflammation.
著者:: Antoniades, C, 等
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Genetic Polymorphism On Methyl-Tetrahydrofolate-Reductase Affects Vascular Superoxide Generation and Nitric Oxide Bioavailability By Regulating eNOS Coupling in Human Arteries and Veins
著者:: Antoniades, C, 等
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Generation of an iPSC line from a patient with GTP cyclohydrolase 1 (GCH1) deficiency: HDMC0061i-GCH1
著者:: Sabine Jung-Klawitter, 等
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Genetic Variability of Methyl-Tetrahydrofolate-Reductase Modifies eNOS Coupling in Human Arteries and Veins: Effects on Vascular Superoxide Generation and Nitric Oxide Bioavailabllity
著者:: Antoniades, C, 等
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Plasma levels of sCD40-ligand interact with homocysteine biosynthetic pathway and predict eNOS coupling in human vessels: effects on vascular redox state
著者:: Antoniades, C, 等
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Soluble CD40-ligand levels are associated with vascular superoxide production and eNOS coupling in human vessels: Interrelationships with homocysteine biosynthetic pathway
著者:: Antoniades, C, 等
出版事項: (2008)

Endothelial-targeted GTP cyclohydrolase I overexpression increases endothelial tetrahydrobiopterin levels and preserves eNOS coupling in eNOS overexpressing mice
著者:: Bendall, J, 等
出版事項: (2004)

CHRONIC ORAL TETRAHYDROBIOPTERIN TREATMENT IN PATIENTS WITH CORONARY ARTERY DISEASE ELEVATES TOTAL BIOPTERIN LEVELS BUT DOES NOT IMPROVE BIOPTERIN REDOX STATUS OR VASCULAR FUNCTION: A RANDOMISED PLACEBO-CONTROLLED TRIAL
著者:: Cunnington, C, 等
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Vascular Homocysteine Versus 5-Methyl-Tetrahydrofolate As Regulators of Vascular Redox and Endothelial Function in Human Vessels
著者:: Antoniades, C, 等
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The common genetic polymorphism C677T of methyltetrahydrofolate reductase regulates nitric oxide bioavailability and vascular superoxide production via modulation of eNOS coupling in human vessels
著者:: Antoniades, C, 等
出版事項: (2007)

Tetrahydrobiopterin- and glutathionylation-dependent regulation of eNOS coupling: Relationships revealed by eNOS glutathionylation mutants in cells with tet-regulated GTP cyclohydrolase I expression
著者:: Crabtree, M, 等
出版事項: (2012)

GTP cyclohydrolase I expression, protein, and activity determine intracellular tetrahydrobiopterin levels, independent of GTP cyclohydrolase feedback regulatory protein expression.
著者:: Tatham, A, 等
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Plasma asymmetrical-dimethyl-arginine (ADMA) as a regulator of vascular redox and nitric oxide bioavailability in human vessels
著者:: Antoniades, C, 等
出版事項: (2007)

Parkinson's disease in GTP cyclohydrolase 1 mutation carriers.
著者:: Ryan, B, 等
出版事項: (2014)

Chronic oral tetrahydrobiopterin therapy in coronary artery disease elevates total biopterin levels but does not improve redox status or vascular function: a randomized placebo-controlled trial
著者:: Cunnington, C, 等
出版事項: (2010)

Relationships between nitric oxide-mediated endothelial function, eNOS coupling and blood pressure revealed by eNOS-GTP cyclohydrolase 1 double transgenic mice.
著者:: Adlam, D, 等
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GTP cyclohydrolase II structure and mechanism.
著者:: Ren, J, 等
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Atorvastatin directly improves vascular redox state by affecting eNOS coupling and NADPH-oxidase activity in human vein grafts ex-vivo
著者:: Bakogiannis, C, 等
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Stoichiometric relationships between endothelial tetrahydrobiopterin, endothelial NO synthase (eNOS) activity, and eNOS coupling in vivo: insights from transgenic mice with endothelial-targeted GTP cyclohydrolase 1 and eNOS overexpression.
著者:: Bendall, J, 等
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Vascular Homocysteine vs 5-Methyl-Tetrahydrofolate as Regulators of Vascular Redox and Endothelial Function in Human Vessels
著者:: Antoniades, C, 等
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Does the pain-protective GTP cyclohydrolase haplotype significantly alter the pattern or severity of pain in humans with chronic pancreatitis?
著者:: Anderson Michelle A, 等
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Nitric oxide Bioavailability is preserved in diabetes by increased endothelial tetrahydrobiopterin synthesis in targeted GTP cyclohydrolase transgenic mice
著者:: Alp, N, 等
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GTP cyclohydrolase I deficiency results in oxidative stress and pulmonary hypertension
著者:: Khoo, J, 等
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Association of plasma asymmetrical dimethylarginine (ADMA) with elevated vascular superoxide production and endothelial nitric oxide synthase uncoupling: implications for endothelial function in human atherosclerosis.
著者:: Antoniades, C, 等
出版事項: (2009)

A Novel Haplotype on GCH1 Gene, Encoding GTP Cyclohydrolase 1, Regulates Vascular Biopterin Synthesis, eNOS Coupling and Vascular Redox in Human Vessels

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