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A Novel Haplotype on GCH1 Gene, Encoding GTP Cyclohydrolase 1, Regulates Vascular Biopterin Synthesis, eNOS Coupling and Vascular Redox in Human Vessels

A Novel Haplotype on GCH1 Gene, Encoding GTP Cyclohydrolase 1, Regulates Vascular Biopterin Synthesis, eNOS Coupling and Vascular Redox in Human Vessels

Dades bibliogràfiques
Autors principals: Antoniades, C, Shirodaria, C, Guzik, T, Van-Assche, T, Pillai, R, Lotsch, J, Tousoulis, D, Stefanadis, C, Tegeder, I, Channon, K
Format: Conference item
Publicat: 2008
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  • Genetic variation in GCH1, encoding GTP-cyclohydrolase 1, regulates biopterin levels and endothelial function in atherosclerosis
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  • Clinical genetics of functionally mild non-coding GTP cyclohydrolase 1 (GCH1) polymorphisms modulating pain and cardiovascular risk.
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  • Rapid Effects of Atorvastatin on Tetrahydrobiopterin-Mediated eNOS Coupling in Human Arteries, is Mediated by Stimulation of Vascular GTP-Cyclohydrolase
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  • Polymorphism of MTHFR gene affects vascular redox and nitric oxide bioavailability by modifying eNOS coupling
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