A Novel Haplotype on GCH1 Gene, Encoding GTP Cyclohydrolase 1, Regulates Vascular Biopterin Synthesis, eNOS Coupling and Vascular Redox in Human Vessels

Geahča maid

• Genetic variation in GCH1, encoding GTP-cyclohydrolase 1, regulates biopterin levels and endothelial function in atherosclerosis
  Dahkki: Van, A, et al.
  Almmustuhtton: (2008)
• GCH1 haplotype determines vascular and plasma biopterin availability in coronary artery disease effects on vascular superoxide production and endothelial function.
  Dahkki: Antoniades, C, et al.
  Almmustuhtton: (2008)
• Clinical genetics of functionally mild non-coding GTP cyclohydrolase 1 (GCH1) polymorphisms modulating pain and cardiovascular risk.
  Dahkki: Doehring, A, et al.
  Almmustuhtton: (2008)
• Rapid Effects of Atorvastatin on Tetrahydrobiopterin-Mediated eNOS Coupling in Human Arteries, is Mediated by Stimulation of Vascular GTP-Cyclohydrolase
  Dahkki: Antoniades, C, et al.
  Almmustuhtton: (2011)
• Polymorphism of MTHFR gene affects vascular redox and nitric oxide bioavailability by modifying eNOS coupling
  Dahkki: Antoniades, C, et al.
  Almmustuhtton: (2008)