Finding the missing heritability of complex diseases.

Finding the missing heritability of complex diseases.

Genome-wide association studies have identified hundreds of genetic variants associated with complex human diseases and traits, and have provided valuable insights into their genetic architecture. Most variants identified so far confer relatively small increments in risk, and explain only a small pr...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид:	Manolio, T, Collins, F, Cox, N, Goldstein, D, Hindorff, L, Hunter, D, McCarthy, M, Ramos, E, Cardon, L, Chakravarti, A, Cho, J, Guttmacher, A, Kong, A, Kruglyak, L, Mardis, E, Rotimi, C, Slatkin, M, Valle, D, Whittemore, A, Boehnke, M, Clark, A, Eichler, E, Gibson, G, Haines, J, Mackay, T
Формат:	Journal article
Хэл сонгох:	English
Хэвлэсэн:	2009

Ижил төстэй зүйлс

Ovarian morphology is a marker of heritable biochemical traits in sisters with polycystic ovaries.
-н: Franks, S, зэрэг
Хэвлэсэн: (2008)

Heritability of variation in glycaemic response to metformin: A genome-wide complex trait analysis
-н: Zhou, K, зэрэг
Хэвлэсэн: (2014)

On negative heritability and negative estimates of heritability
-н: Steinsaltz, D, зэрэг
Хэвлэсэн: (2020)

Replicating genotype-phenotype associations.
-н: Chanock, S, зэрэг
Хэвлэсэн: (2007)

Missing heritability and strategies for finding the underlying causes of complex disease.
-н: Eichler, E, зэрэг
Хэвлэсэн: (2010)

Education policy and the heritability of educational attainment
-н: A.C. Heath, зэрэг
Хэвлэсэн: (2016-07-01)

Heritability of variation in glycaemic response to metformin: a genome-wide complex trait analysis.
-н: Zhou, K, зэрэг
Хэвлэсэн: (2014)

Environmental coupling of selection and heritability limits evolution.
-н: A J Wilson, зэрэг
Хэвлэсэн: (2006-07-01)

Learning and memory deficits produced by aspartame are heritable via the paternal lineage
-н: Sara K. Jones, зэрэг
Хэвлэсэн: (2023-08-01)

How useful is the fine-scale mapping of complex trait linkage peaks? Evaluating the impact of additional microsatellite genotyping on the posterior probability of linkage.
-н: Wiltshire, S, зэрэг
Хэвлэсэн: (2005)

Patterns of pharmacogenetic variation in nine biogeographic groups
-н: Sophia Hernandez, зэрэг
Хэвлэсэн: (2024-09-01)

Evaluating results from genome-wide linkage scans of complex discrete traits by locus counting.
-н: Wiltshire, S, зэрэг
Хэвлэсэн: (2002)

Evaluating the results of genomewide linkage scans of complex traits by locus counting.
-н: Wiltshire, S, зэрэг
Хэвлэсэн: (2002)

Aberrant hypothalamic-pituitary-ovarian axis in the Watanabe heritable hyperlipidemic rabbit.
-н: E D Robins, зэрэг
Хэвлэсэн: (1994-01-01)

Heritability of attractiveness to mosquitoes.
-н: G Mandela Fernández-Grandon, зэрэг
Хэвлэсэн: (2015-01-01)

Genome-wide association studies for complex traits: consensus, uncertainty and challenges.
-н: McCarthy, M, зэрэг
Хэвлэсэн: (2008)

Will the real disease gene please stand up?
-н: Shephard, N, зэрэг
Хэвлэсэн: (2005)

The effect of sample size on tagging SNP performance and consequences for complex disease gene mapping
-н: Zeggini, E, зэрэг
Хэвлэсэн: (2005)

Trait heritability in major transitions
-н: Matthew D. Herron, зэрэг
Хэвлэсэн: (2018-12-01)

Inferred relatedness and heritability in malaria parasites.
-н: Anderson, T, зэрэг
Хэвлэсэн: (2010)

Heritability and genetic variance of dementia with Lewy bodies
-н: Guerreiro, R, зэрэг
Хэвлэсэн: (2019)

P11.30 HERITABILITY OF CENTRAL BLOOD PRESSURE AND PULSE PRESSURE – A TWIN STUDY
-н: A.D. Tarnoki, зэрэг
Хэвлэсэн: (2011-11-01)

Identification of a heritable polymorphism in bovine PRNP associated with genetic transmissible spongiform encephalopathy: evidence of heritable BSE.
-н: Eric M Nicholson, зэрэг
Хэвлэсэн: (2008-01-01)

Temperament and its heritability in Corriedale and Merino lambs
-н: N. Zambra, зэрэг
Хэвлэсэн: (2015-01-01)

Heritability estimates for beta cell function and features of the insulin resistance syndrome in UK families with an increased susceptibility to type 2 diabetes.
-н: Mills, G, зэрэг
Хэвлэсэн: (2004)

Genetic architecture of heritable leaf microbes
-н: Julia A. Boyle, зэрэг
Хэвлэсэн: (2024-07-01)

Heritability of semantic verbal fluency task using time-interval analysis.
-н: T P Taporoski, зэрэг
Хэвлэсэн: (2019-01-01)

Egg shell quality in Japanese quail: characteristics, heritabilities and genetic and phenotypic relationships
-н: D. Narinc, зэрэг
Хэвлэсэн: (2015-01-01)

The curse of the missing heritability
-н: Xia eShen
Хэвлэсэн: (2013-11-01)

Endocranial volume is heritable and is associated with longevity and fitness in a wild mammal
-н: C. J. Logan, зэрэг
Хэвлэсэн: (2016-01-01)

Heritability of Blood Pressure in an Iranian Population
-н: M Saadat, зэрэг
Хэвлэсэн: (2001-06-01)

Heritability of Blood Pressure in an Iranian Population
-н: M Saadat, зэрэг
Хэвлэсэн: (2001-07-01)

Epigenetics, heritability and longitudinal analysis
-н: Haakon E. Nustad, зэрэг
Хэвлэсэн: (2018-09-01)

Analysis of shared heritability in common disorders of the brain
-н: Anttila, V, зэрэг
Хэвлэсэн: (2018)

Heritability of phenotypic udder traits to improve resilience to mastitis in Texel ewes
-н: R.E. Crump, зэрэг
Хэвлэсэн: (2019-01-01)

The heritability of multi-modal connectivity in human brain activity
-н: Colclough, G, зэрэг
Хэвлэсэн: (2017)

Heritability of working in a creative profession
-н: Roeling, M, зэрэг
Хэвлэсэн: (2016)

05.02 HERITABILITY AND INTRAFAMILIAL AGGREGATION OF ARTERIAL CHARACTERISTICS
-н: J.S. Seidlerova, зэрэг
Хэвлэсэн: (2007-08-01)

Genetic variability, heritability and genetic advance in litchi (Litchi chinensis)
-н: E S MARBOH, зэрэг
Хэвлэсэн: (2018-10-01)

Trans-ancestral genome-wide association study of longitudinal pubertal height growth and shared heritability with adult health outcomes
-н: Bradfield, JP, зэрэг
Хэвлэсэн: (2024)