Inhibition of leucocyte motility by drugs used in ulcerative colitis.
The effects on leucocyte motility of sulphasalazine (Salazopyrin) and its metabolites sulphapyridine and 5 amino-salicylic acid have been compared with those of prednisolone and indomethacin. Sulphasalazine, its active metabolite 5 amino-salicylic acid, and prednisolone are all potent inhibitors of...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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1981
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| _version_ | 1797069266056380416 |
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| author | Rhodes, J Bartholomew, T Jewell, D |
| author_facet | Rhodes, J Bartholomew, T Jewell, D |
| author_sort | Rhodes, J |
| collection | OXFORD |
| description | The effects on leucocyte motility of sulphasalazine (Salazopyrin) and its metabolites sulphapyridine and 5 amino-salicylic acid have been compared with those of prednisolone and indomethacin. Sulphasalazine, its active metabolite 5 amino-salicylic acid, and prednisolone are all potent inhibitors of leucocyte motility. Sulphapyridine and indomethacin are non-inhibitory. Inhibition of leucocyte motility may explain why sulphasalazine and 5 amino-salicylic acid are effective in ulcerative colitis while sulphapyridine is not. The lack of effect of indomethacin suggests that this action of sulphasalazine does not involve inhibition of prostaglandin synthesis. |
| first_indexed | 2024-03-06T22:21:55Z |
| format | Journal article |
| id | oxford-uuid:5557925c-44b3-4764-af61-560d204c0dac |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:21:55Z |
| publishDate | 1981 |
| record_format | dspace |
| spelling | oxford-uuid:5557925c-44b3-4764-af61-560d204c0dac2022-03-26T16:43:21ZInhibition of leucocyte motility by drugs used in ulcerative colitis.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:5557925c-44b3-4764-af61-560d204c0dacEnglishSymplectic Elements at Oxford1981Rhodes, JBartholomew, TJewell, DThe effects on leucocyte motility of sulphasalazine (Salazopyrin) and its metabolites sulphapyridine and 5 amino-salicylic acid have been compared with those of prednisolone and indomethacin. Sulphasalazine, its active metabolite 5 amino-salicylic acid, and prednisolone are all potent inhibitors of leucocyte motility. Sulphapyridine and indomethacin are non-inhibitory. Inhibition of leucocyte motility may explain why sulphasalazine and 5 amino-salicylic acid are effective in ulcerative colitis while sulphapyridine is not. The lack of effect of indomethacin suggests that this action of sulphasalazine does not involve inhibition of prostaglandin synthesis. |
| spellingShingle | Rhodes, J Bartholomew, T Jewell, D Inhibition of leucocyte motility by drugs used in ulcerative colitis. |
| title | Inhibition of leucocyte motility by drugs used in ulcerative colitis. |
| title_full | Inhibition of leucocyte motility by drugs used in ulcerative colitis. |
| title_fullStr | Inhibition of leucocyte motility by drugs used in ulcerative colitis. |
| title_full_unstemmed | Inhibition of leucocyte motility by drugs used in ulcerative colitis. |
| title_short | Inhibition of leucocyte motility by drugs used in ulcerative colitis. |
| title_sort | inhibition of leucocyte motility by drugs used in ulcerative colitis |
| work_keys_str_mv | AT rhodesj inhibitionofleucocytemotilitybydrugsusedinulcerativecolitis AT bartholomewt inhibitionofleucocytemotilitybydrugsusedinulcerativecolitis AT jewelld inhibitionofleucocytemotilitybydrugsusedinulcerativecolitis |