CCR2-mediated antiinflammatory effects of endothelial tetrahydrobiopterin inhibit vascular injury-induced accelerated atherosclerosis.

CCR2-mediated antiinflammatory effects of endothelial tetrahydrobiopterin inhibit vascular injury-induced accelerated atherosclerosis.

BACKGROUND: Vascular injury results in loss of endothelial nitric oxide (NO), production of reactive oxygen species (ROS), and the initiation of an inflammatory response. Both NO and ROS modulate inflammation through redox-sensitive pathways. Tetrahydrobiopterin (BH4) is an essential cofactor for en...

Bibliográfalaš dieđut
Váldodahkkit:	Ali, Z, Bursill, C, Douglas, G, McNeill, E, Papaspyridonos, M, Tatham, A, Bendall, J, Akhtar, A, Alp, N, Greaves, D, Channon, K
Materiálatiipa:	Conference item
Almmustuhtton:	2008

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