Characterizing antimicrobial resistance in chicken pathogens: a step towards improved antimicrobial stewardship in poultry production in Vietnam
In the Mekong Delta of Vietnam, farmers use large quantities of antimicrobials to raise small-scale chicken flocks, often including active ingredients regarded of "critical importance'" by the World Health Organization. Due to limitations in laboratory capacity, the choice of antimicr...
| Main Authors: | , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
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MDPI
2020
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| _version_ | 1797069278777704448 |
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| author | Yen, NTP Nhung, NT Van, NTB Cuong, NV Kiet, BT Phu, DH Hien, VB Campbell, J Chansiripornchai, N Thwaites, GE Carrique-Mas, JJ |
| author_facet | Yen, NTP Nhung, NT Van, NTB Cuong, NV Kiet, BT Phu, DH Hien, VB Campbell, J Chansiripornchai, N Thwaites, GE Carrique-Mas, JJ |
| author_sort | Yen, NTP |
| collection | OXFORD |
| description | In the Mekong Delta of Vietnam, farmers use large quantities of antimicrobials to raise small-scale chicken flocks, often including active ingredients regarded of "critical importance'" by the World Health Organization. Due to limitations in laboratory capacity, the choice of antimicrobials normally does not follow any empirical criteria of effectiveness. The aim of this study was to highlight non-critically important antimicrobials against which chicken pathogens are likely to be susceptible as a basis for treatment guidelines. Microtiter broth dilution method was performed to determine the minimal inhibitory concentration (MIC) of 12 commonly used antimicrobials for 58 isolates, including Ornithobacterium rhinotracheale (ORT) (n = 22), Gallibacterium anatis (n = 19), and Avibacterium endocarditidis (n = 17). Unfortunately, internationally accepted breakpoints for resistance in these organisms do not exist. We drew tentative epidemiological cut-offs (TECOFFs) for those antimicrobial-pathogen combinations where MIC distributions suggested the presence of a distinct non-wild-type population. Based on the observed results, doxycycline would be the drug of choice for A.endocarditidis (11.8% presumptive non-wild type) and G. anatis infections (5.3% presumptive non-wild type). A total of 13.6% ORT isolates were non-wild type with regards to oxytetracycline, making it the drug of choice against this pathogen. This study illustrates the challenges in interpreting susceptibility testing results and the need to establish internationally accepted breakpoints for veterinary pathogens. |
| first_indexed | 2024-03-06T22:22:05Z |
| format | Journal article |
| id | oxford-uuid:5565adb6-99bb-453f-8629-7d44499521e2 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:22:05Z |
| publishDate | 2020 |
| publisher | MDPI |
| record_format | dspace |
| spelling | oxford-uuid:5565adb6-99bb-453f-8629-7d44499521e22022-03-26T16:43:46ZCharacterizing antimicrobial resistance in chicken pathogens: a step towards improved antimicrobial stewardship in poultry production in VietnamJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:5565adb6-99bb-453f-8629-7d44499521e2EnglishSymplectic ElementsMDPI 2020Yen, NTPNhung, NTVan, NTBCuong, NVKiet, BTPhu, DHHien, VBCampbell, JChansiripornchai, NThwaites, GECarrique-Mas, JJIn the Mekong Delta of Vietnam, farmers use large quantities of antimicrobials to raise small-scale chicken flocks, often including active ingredients regarded of "critical importance'" by the World Health Organization. Due to limitations in laboratory capacity, the choice of antimicrobials normally does not follow any empirical criteria of effectiveness. The aim of this study was to highlight non-critically important antimicrobials against which chicken pathogens are likely to be susceptible as a basis for treatment guidelines. Microtiter broth dilution method was performed to determine the minimal inhibitory concentration (MIC) of 12 commonly used antimicrobials for 58 isolates, including Ornithobacterium rhinotracheale (ORT) (n = 22), Gallibacterium anatis (n = 19), and Avibacterium endocarditidis (n = 17). Unfortunately, internationally accepted breakpoints for resistance in these organisms do not exist. We drew tentative epidemiological cut-offs (TECOFFs) for those antimicrobial-pathogen combinations where MIC distributions suggested the presence of a distinct non-wild-type population. Based on the observed results, doxycycline would be the drug of choice for A.endocarditidis (11.8% presumptive non-wild type) and G. anatis infections (5.3% presumptive non-wild type). A total of 13.6% ORT isolates were non-wild type with regards to oxytetracycline, making it the drug of choice against this pathogen. This study illustrates the challenges in interpreting susceptibility testing results and the need to establish internationally accepted breakpoints for veterinary pathogens. |
| spellingShingle | Yen, NTP Nhung, NT Van, NTB Cuong, NV Kiet, BT Phu, DH Hien, VB Campbell, J Chansiripornchai, N Thwaites, GE Carrique-Mas, JJ Characterizing antimicrobial resistance in chicken pathogens: a step towards improved antimicrobial stewardship in poultry production in Vietnam |
| title | Characterizing antimicrobial resistance in chicken pathogens: a step towards improved antimicrobial stewardship in poultry production in Vietnam |
| title_full | Characterizing antimicrobial resistance in chicken pathogens: a step towards improved antimicrobial stewardship in poultry production in Vietnam |
| title_fullStr | Characterizing antimicrobial resistance in chicken pathogens: a step towards improved antimicrobial stewardship in poultry production in Vietnam |
| title_full_unstemmed | Characterizing antimicrobial resistance in chicken pathogens: a step towards improved antimicrobial stewardship in poultry production in Vietnam |
| title_short | Characterizing antimicrobial resistance in chicken pathogens: a step towards improved antimicrobial stewardship in poultry production in Vietnam |
| title_sort | characterizing antimicrobial resistance in chicken pathogens a step towards improved antimicrobial stewardship in poultry production in vietnam |
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