The enzymes of β-lactam biosynthesis.
The β-lactam antibiotics and related β-lactamase inhibitors are amongst the most important small molecules in clinical use. Most, but not all, β-lactams including penicillins, cephalosporins, and clavulanic acid are produced via fermentation or via modification of fermented intermediates, with impor...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2013
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| _version_ | 1797069279187697664 |
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| author | Hamed, R Gomez-Castellanos, JR Henry, L Ducho, C McDonough, M Schofield, C |
| author_facet | Hamed, R Gomez-Castellanos, JR Henry, L Ducho, C McDonough, M Schofield, C |
| author_sort | Hamed, R |
| collection | OXFORD |
| description | The β-lactam antibiotics and related β-lactamase inhibitors are amongst the most important small molecules in clinical use. Most, but not all, β-lactams including penicillins, cephalosporins, and clavulanic acid are produced via fermentation or via modification of fermented intermediates, with important exceptions being the carbapenems and aztreonam. The desire for more efficient routes to existing antibiotics and for access to new and synthetically challenging ones stimulates continued interest in β-lactam biosynthesis. We review knowledge of the pathways leading to β-lactam antibiotics focusing on the mechanisms, structures and biocatalytic applications of the enzymes involved. |
| first_indexed | 2024-03-06T22:22:06Z |
| format | Journal article |
| id | oxford-uuid:55662fac-7d97-4813-8d04-bdd9cb01874d |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:22:06Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | oxford-uuid:55662fac-7d97-4813-8d04-bdd9cb01874d2022-03-26T16:43:49ZThe enzymes of β-lactam biosynthesis.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:55662fac-7d97-4813-8d04-bdd9cb01874dEnglishSymplectic Elements at Oxford2013Hamed, RGomez-Castellanos, JRHenry, LDucho, CMcDonough, MSchofield, CThe β-lactam antibiotics and related β-lactamase inhibitors are amongst the most important small molecules in clinical use. Most, but not all, β-lactams including penicillins, cephalosporins, and clavulanic acid are produced via fermentation or via modification of fermented intermediates, with important exceptions being the carbapenems and aztreonam. The desire for more efficient routes to existing antibiotics and for access to new and synthetically challenging ones stimulates continued interest in β-lactam biosynthesis. We review knowledge of the pathways leading to β-lactam antibiotics focusing on the mechanisms, structures and biocatalytic applications of the enzymes involved. |
| spellingShingle | Hamed, R Gomez-Castellanos, JR Henry, L Ducho, C McDonough, M Schofield, C The enzymes of β-lactam biosynthesis. |
| title | The enzymes of β-lactam biosynthesis. |
| title_full | The enzymes of β-lactam biosynthesis. |
| title_fullStr | The enzymes of β-lactam biosynthesis. |
| title_full_unstemmed | The enzymes of β-lactam biosynthesis. |
| title_short | The enzymes of β-lactam biosynthesis. |
| title_sort | enzymes of β lactam biosynthesis |
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