Comparison of imipenem and ceftazidime as therapy for severe melioidosis.
An open, prospective, randomized, comparative treatment trial was conducted to compare the therapeutic efficacy of high-dose intravenous imipenem and ceftazidime for acute severe melioidosis. Adult Thai patients with suspected acute, severe melioidosis were randomized to receive either imipenem, at...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1999
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| _version_ | 1797069309887905792 |
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| author | Simpson, A Suputtamongkol, Y Smith, MD Angus, B Rajanuwong, A Wuthiekanun, V Howe, P Walsh, A Chaowagul, W White, N |
| author_facet | Simpson, A Suputtamongkol, Y Smith, MD Angus, B Rajanuwong, A Wuthiekanun, V Howe, P Walsh, A Chaowagul, W White, N |
| author_sort | Simpson, A |
| collection | OXFORD |
| description | An open, prospective, randomized, comparative treatment trial was conducted to compare the therapeutic efficacy of high-dose intravenous imipenem and ceftazidime for acute severe melioidosis. Adult Thai patients with suspected acute, severe melioidosis were randomized to receive either imipenem, at a dosage of 50 mg/(kg x d), or ceftazidime, at a dosage of 120 mg/(kg x d), for a minimum of 10 days. The main outcome measures were death or treatment failure. Of the 296 patients enrolled, 214 had culture-confirmed melioidosis, and 132 (61.7%) of them had positive blood cultures. Mortality among patients with melioidosis was 36.9% overall. There were no differences in survival overall (P = .96) or after 48 hours (P = .3). Treatment failure after 48 hours was more common among patients treated with ceftazidime (P = .011). Both treatments were well tolerated. Imipenem is a safe and effective treatment for acute severe melioidosis and may be considered an alternative to ceftazidime. |
| first_indexed | 2024-03-06T22:22:32Z |
| format | Journal article |
| id | oxford-uuid:558cb026-c41f-42a9-8106-ab88cb7e1ad9 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:22:32Z |
| publishDate | 1999 |
| record_format | dspace |
| spelling | oxford-uuid:558cb026-c41f-42a9-8106-ab88cb7e1ad92022-03-26T16:44:42ZComparison of imipenem and ceftazidime as therapy for severe melioidosis.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:558cb026-c41f-42a9-8106-ab88cb7e1ad9EnglishSymplectic Elements at Oxford1999Simpson, ASuputtamongkol, YSmith, MDAngus, BRajanuwong, AWuthiekanun, VHowe, PWalsh, AChaowagul, WWhite, NAn open, prospective, randomized, comparative treatment trial was conducted to compare the therapeutic efficacy of high-dose intravenous imipenem and ceftazidime for acute severe melioidosis. Adult Thai patients with suspected acute, severe melioidosis were randomized to receive either imipenem, at a dosage of 50 mg/(kg x d), or ceftazidime, at a dosage of 120 mg/(kg x d), for a minimum of 10 days. The main outcome measures were death or treatment failure. Of the 296 patients enrolled, 214 had culture-confirmed melioidosis, and 132 (61.7%) of them had positive blood cultures. Mortality among patients with melioidosis was 36.9% overall. There were no differences in survival overall (P = .96) or after 48 hours (P = .3). Treatment failure after 48 hours was more common among patients treated with ceftazidime (P = .011). Both treatments were well tolerated. Imipenem is a safe and effective treatment for acute severe melioidosis and may be considered an alternative to ceftazidime. |
| spellingShingle | Simpson, A Suputtamongkol, Y Smith, MD Angus, B Rajanuwong, A Wuthiekanun, V Howe, P Walsh, A Chaowagul, W White, N Comparison of imipenem and ceftazidime as therapy for severe melioidosis. |
| title | Comparison of imipenem and ceftazidime as therapy for severe melioidosis. |
| title_full | Comparison of imipenem and ceftazidime as therapy for severe melioidosis. |
| title_fullStr | Comparison of imipenem and ceftazidime as therapy for severe melioidosis. |
| title_full_unstemmed | Comparison of imipenem and ceftazidime as therapy for severe melioidosis. |
| title_short | Comparison of imipenem and ceftazidime as therapy for severe melioidosis. |
| title_sort | comparison of imipenem and ceftazidime as therapy for severe melioidosis |
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