Vitamin D influences asthmatic pathology through its action on diverse immunological pathways
The prevalence of vitamin D insufficiency and deficiency has increased markedly in recent decades to current epidemic levels (Hyppönen E, et al. Am J Clin Nutr 2007;85:860–868). In parallel, there has been an increase in the incidence of a range of immune-mediated conditions ranging from cancer to a...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
American Thoracic Society
2014
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| _version_ | 1824458683034107904 |
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| author | Pfeffer, PE Mann, E Hornsby, E Chambers, ES Chen, Y Rice, L Hawrylowicz, CM |
| author_facet | Pfeffer, PE Mann, E Hornsby, E Chambers, ES Chen, Y Rice, L Hawrylowicz, CM |
| author_sort | Pfeffer, PE |
| collection | OXFORD |
| description | The prevalence of vitamin D insufficiency and deficiency has increased markedly in recent decades to current epidemic levels (Hyppönen E, et al. Am J Clin Nutr 2007;85:860–868). In parallel, there has been an increase in the incidence of a range of immune-mediated conditions ranging from cancer to autoimmune and respiratory diseases, including chronic obstructive pulmonary disease and asthma (Holick MF. N Engl J Med 2007;357:266–281; Finklea et al. Adv Nutr 2011;2:244–253). There is also an association with increased respiratory infections, which are the most common cause of asthma exacerbations (Finklea et al. Adv Nutr 2011;2:244–253). Together, this has resulted in considerable interest in the therapeutic potential of vitamin D to prevent and improve treatment of asthma and other respiratory diseases. To this end, data from clinical trials involving supplementation with active vitamin D, or more commonly a precursor, are starting to emerge. This review considers mechanisms by which vitamin D may act on the immune system to dampen inappropriate inflammatory responses in the airway while also promoting tolerance and antimicrobial defense mechanisms that collectively maintain respiratory health. |
| first_indexed | 2025-02-19T04:29:47Z |
| format | Journal article |
| id | oxford-uuid:558f8db8-2c93-4af4-82ad-7bf23cd36533 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2025-02-19T04:29:47Z |
| publishDate | 2014 |
| publisher | American Thoracic Society |
| record_format | dspace |
| spelling | oxford-uuid:558f8db8-2c93-4af4-82ad-7bf23cd365332024-12-17T11:29:29ZVitamin D influences asthmatic pathology through its action on diverse immunological pathwaysJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:558f8db8-2c93-4af4-82ad-7bf23cd36533EnglishSymplectic Elements at OxfordAmerican Thoracic Society2014Pfeffer, PEMann, EHornsby, EChambers, ESChen, YRice, LHawrylowicz, CMThe prevalence of vitamin D insufficiency and deficiency has increased markedly in recent decades to current epidemic levels (Hyppönen E, et al. Am J Clin Nutr 2007;85:860–868). In parallel, there has been an increase in the incidence of a range of immune-mediated conditions ranging from cancer to autoimmune and respiratory diseases, including chronic obstructive pulmonary disease and asthma (Holick MF. N Engl J Med 2007;357:266–281; Finklea et al. Adv Nutr 2011;2:244–253). There is also an association with increased respiratory infections, which are the most common cause of asthma exacerbations (Finklea et al. Adv Nutr 2011;2:244–253). Together, this has resulted in considerable interest in the therapeutic potential of vitamin D to prevent and improve treatment of asthma and other respiratory diseases. To this end, data from clinical trials involving supplementation with active vitamin D, or more commonly a precursor, are starting to emerge. This review considers mechanisms by which vitamin D may act on the immune system to dampen inappropriate inflammatory responses in the airway while also promoting tolerance and antimicrobial defense mechanisms that collectively maintain respiratory health. |
| spellingShingle | Pfeffer, PE Mann, E Hornsby, E Chambers, ES Chen, Y Rice, L Hawrylowicz, CM Vitamin D influences asthmatic pathology through its action on diverse immunological pathways |
| title | Vitamin D influences asthmatic pathology through its action on diverse immunological pathways |
| title_full | Vitamin D influences asthmatic pathology through its action on diverse immunological pathways |
| title_fullStr | Vitamin D influences asthmatic pathology through its action on diverse immunological pathways |
| title_full_unstemmed | Vitamin D influences asthmatic pathology through its action on diverse immunological pathways |
| title_short | Vitamin D influences asthmatic pathology through its action on diverse immunological pathways |
| title_sort | vitamin d influences asthmatic pathology through its action on diverse immunological pathways |
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