The activity of JmjC histone lysine demethylase KDM4A is highly sensitive to oxygen concentrations
The JmjC histone lysine demethylases (KDMs) are epigenetic regulators involved in the removal of methyl groups from post-translationally modified lysyl residues within histone tails, modulating gene transcription. These enzymes require molecular oxygen for catalytic activity and, as 2-oxoglutarate (...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Published: |
American Chemical Society
2017
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