The impact of trisomy 21 on epidemiology, management, and outcomes of congenital duodenal obstruction: a population-based study
<p><strong>Purpose</strong> Congenital duodenal obstruction (CDO) is associated with trisomy 21 (T21), or Down’s syndrome, in around a third of infants. The aim of this study was to explore the impact of T21 on the epidemiology, management, and outcomes of infants with CDO.</p&g...
| Autores principales: | , , , |
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| Formato: | Journal article |
| Lenguaje: | English |
| Publicado: |
Springer Verlag
2020
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| _version_ | 1826273101617299456 |
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| author | Bethell, GS Long, AM Knight, M Hall, NJ |
| author_facet | Bethell, GS Long, AM Knight, M Hall, NJ |
| author_sort | Bethell, GS |
| collection | OXFORD |
| description | <p><strong>Purpose</strong>
Congenital duodenal obstruction (CDO) is associated with trisomy 21 (T21), or Down’s syndrome, in around a third of infants. The aim of this study was to explore the impact of T21 on the epidemiology, management, and outcomes of infants with CDO.</p>
<p><strong>Methods</strong>
Data were prospectively collected from specialist neonatal surgical centres in the United Kingdom over a 12 month period from March 2016 using established population-based methodology for all babies with CDO. Infants with T21 were compared to those without any chromosomal anomaly.</p>
<p><strong>Results</strong>
Of 102 infants with CDO that underwent operative repair, T21 was present in 33 [32% (95% CI 23–41%)] babies. Cardiac anomalies were more common in those with T21 compared to those without a chromosomal anomaly (91 vs 17%, p < 0.001), whereas associated gastrointestinal anomalies were less common in infants with T21 (3 vs 12%, p = 0.03). Surgical management was not influenced by T21. Time to achieve full enteral feed, need for repeat related surgery, and mortality were similar between groups. Infants with T21 had a longer median initial inpatient stay (23 vs 16.5 days, p = 0.02).</p>
<p><strong>Conclusions</strong>
Infants with T21 have a higher incidence of cardiac anomalies and a longer initial inpatient stay; however, it does not change CDO management or outcomes. This information is important for prenatal and postnatal counselling of parents of infants with CDO and T21.</p> |
| first_indexed | 2024-03-06T22:23:03Z |
| format | Journal article |
| id | oxford-uuid:55b8d910-7b54-42a0-99a5-39fd9f6b74d4 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:23:03Z |
| publishDate | 2020 |
| publisher | Springer Verlag |
| record_format | dspace |
| spelling | oxford-uuid:55b8d910-7b54-42a0-99a5-39fd9f6b74d42022-03-26T16:45:48ZThe impact of trisomy 21 on epidemiology, management, and outcomes of congenital duodenal obstruction: a population-based studyJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:55b8d910-7b54-42a0-99a5-39fd9f6b74d4EnglishSymplectic ElementsSpringer Verlag2020Bethell, GSLong, AMKnight, MHall, NJ<p><strong>Purpose</strong> Congenital duodenal obstruction (CDO) is associated with trisomy 21 (T21), or Down’s syndrome, in around a third of infants. The aim of this study was to explore the impact of T21 on the epidemiology, management, and outcomes of infants with CDO.</p> <p><strong>Methods</strong> Data were prospectively collected from specialist neonatal surgical centres in the United Kingdom over a 12 month period from March 2016 using established population-based methodology for all babies with CDO. Infants with T21 were compared to those without any chromosomal anomaly.</p> <p><strong>Results</strong> Of 102 infants with CDO that underwent operative repair, T21 was present in 33 [32% (95% CI 23–41%)] babies. Cardiac anomalies were more common in those with T21 compared to those without a chromosomal anomaly (91 vs 17%, p < 0.001), whereas associated gastrointestinal anomalies were less common in infants with T21 (3 vs 12%, p = 0.03). Surgical management was not influenced by T21. Time to achieve full enteral feed, need for repeat related surgery, and mortality were similar between groups. Infants with T21 had a longer median initial inpatient stay (23 vs 16.5 days, p = 0.02).</p> <p><strong>Conclusions</strong> Infants with T21 have a higher incidence of cardiac anomalies and a longer initial inpatient stay; however, it does not change CDO management or outcomes. This information is important for prenatal and postnatal counselling of parents of infants with CDO and T21.</p> |
| spellingShingle | Bethell, GS Long, AM Knight, M Hall, NJ The impact of trisomy 21 on epidemiology, management, and outcomes of congenital duodenal obstruction: a population-based study |
| title | The impact of trisomy 21 on epidemiology, management, and outcomes of congenital duodenal obstruction: a population-based study |
| title_full | The impact of trisomy 21 on epidemiology, management, and outcomes of congenital duodenal obstruction: a population-based study |
| title_fullStr | The impact of trisomy 21 on epidemiology, management, and outcomes of congenital duodenal obstruction: a population-based study |
| title_full_unstemmed | The impact of trisomy 21 on epidemiology, management, and outcomes of congenital duodenal obstruction: a population-based study |
| title_short | The impact of trisomy 21 on epidemiology, management, and outcomes of congenital duodenal obstruction: a population-based study |
| title_sort | impact of trisomy 21 on epidemiology management and outcomes of congenital duodenal obstruction a population based study |
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