Selective activation of mesolimbic and mesocortical dopamine metabolism in rat brain by infusion of a stable substance P analogue into the ventral tegmental area.
Microinfusion of the metabolically stable substance P (SP) agonist, [pGlu5,MePhe8,Sar9]-SP5-11 (DiMe-C7), into the ventral tegmental area (VTA) of rat brain increased levels of the dopamine (DA) metabolite dihydroxyphenylacetic acid in the prefrontal cortex (+ 120%) and nucleus accumbens (+30%) but...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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1986
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| _version_ | 1826273106798313472 |
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| author | Elliott, P Alpert, J Bannon, M Iversen, S |
| author_facet | Elliott, P Alpert, J Bannon, M Iversen, S |
| author_sort | Elliott, P |
| collection | OXFORD |
| description | Microinfusion of the metabolically stable substance P (SP) agonist, [pGlu5,MePhe8,Sar9]-SP5-11 (DiMe-C7), into the ventral tegmental area (VTA) of rat brain increased levels of the dopamine (DA) metabolite dihydroxyphenylacetic acid in the prefrontal cortex (+ 120%) and nucleus accumbens (+30%) but not in other regions of forebrain. In contrast, infusions of DiMe-C7 or SP into the lateral ventricles or microinfusions of SP into VTA failed to elicit increases in DOPAC levels in forebrain. DA levels were unaffected by SP or DiMe-C7 regardless of the route of administration. These data and previous studies suggest a role for endogenous SP in the modulation of mesocortical and mesolimbic DA neurones. |
| first_indexed | 2024-03-06T22:23:08Z |
| format | Journal article |
| id | oxford-uuid:55be740b-d60b-4357-a85a-2c25f11758f1 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:23:08Z |
| publishDate | 1986 |
| record_format | dspace |
| spelling | oxford-uuid:55be740b-d60b-4357-a85a-2c25f11758f12022-03-26T16:45:56ZSelective activation of mesolimbic and mesocortical dopamine metabolism in rat brain by infusion of a stable substance P analogue into the ventral tegmental area.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:55be740b-d60b-4357-a85a-2c25f11758f1EnglishSymplectic Elements at Oxford1986Elliott, PAlpert, JBannon, MIversen, SMicroinfusion of the metabolically stable substance P (SP) agonist, [pGlu5,MePhe8,Sar9]-SP5-11 (DiMe-C7), into the ventral tegmental area (VTA) of rat brain increased levels of the dopamine (DA) metabolite dihydroxyphenylacetic acid in the prefrontal cortex (+ 120%) and nucleus accumbens (+30%) but not in other regions of forebrain. In contrast, infusions of DiMe-C7 or SP into the lateral ventricles or microinfusions of SP into VTA failed to elicit increases in DOPAC levels in forebrain. DA levels were unaffected by SP or DiMe-C7 regardless of the route of administration. These data and previous studies suggest a role for endogenous SP in the modulation of mesocortical and mesolimbic DA neurones. |
| spellingShingle | Elliott, P Alpert, J Bannon, M Iversen, S Selective activation of mesolimbic and mesocortical dopamine metabolism in rat brain by infusion of a stable substance P analogue into the ventral tegmental area. |
| title | Selective activation of mesolimbic and mesocortical dopamine metabolism in rat brain by infusion of a stable substance P analogue into the ventral tegmental area. |
| title_full | Selective activation of mesolimbic and mesocortical dopamine metabolism in rat brain by infusion of a stable substance P analogue into the ventral tegmental area. |
| title_fullStr | Selective activation of mesolimbic and mesocortical dopamine metabolism in rat brain by infusion of a stable substance P analogue into the ventral tegmental area. |
| title_full_unstemmed | Selective activation of mesolimbic and mesocortical dopamine metabolism in rat brain by infusion of a stable substance P analogue into the ventral tegmental area. |
| title_short | Selective activation of mesolimbic and mesocortical dopamine metabolism in rat brain by infusion of a stable substance P analogue into the ventral tegmental area. |
| title_sort | selective activation of mesolimbic and mesocortical dopamine metabolism in rat brain by infusion of a stable substance p analogue into the ventral tegmental area |
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