Factors controlling fat mobilization from human subcutaneous adipose tissue during exercise.
To investigate possible factors that limit fat utilization during exercise, arteriovenous differences of plasma nonesterified fatty acids (NEFA) and glycerol were measured across the subcutaneous adipose tissue of the anterior abdominal wall in nine subjects who exercised for 60 min at 50-70% of the...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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1991
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| _version_ | 1797069356362891264 |
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| author | Hodgetts, V Coppack, S Frayn, K Hockaday, T |
| author_facet | Hodgetts, V Coppack, S Frayn, K Hockaday, T |
| author_sort | Hodgetts, V |
| collection | OXFORD |
| description | To investigate possible factors that limit fat utilization during exercise, arteriovenous differences of plasma nonesterified fatty acids (NEFA) and glycerol were measured across the subcutaneous adipose tissue of the anterior abdominal wall in nine subjects who exercised for 60 min at 50-70% of their maximal O2 consumption. The large gradient of NEFA concentration from adipose tissue venous to arterial plasma increased throughout the exercise period. Maximal plasma NEFA concentrations in adipose venous drainage were reached postexercise (median 3,800 mumol/l), with a median NEFA-to-albumin molar ratio of 5.7. Fractional reesterification of fatty acids within the tissue (assessed from the ratio of NEFA to glycerol release) was 20-30% in the basal state and declined during exercise. After exercise there was apparently negative reesterification, implying release of NEFA retained in adipose tissue during exercise. Although these findings challenge current views on the regulation of NEFA release, they are in agreement with the concept of supply of fatty acids from adipose tissue as the major factor limiting fat oxidation during sustained exercise. |
| first_indexed | 2024-03-06T22:23:13Z |
| format | Journal article |
| id | oxford-uuid:55c63f3a-4aec-425b-9527-b5b20541a1ab |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:23:13Z |
| publishDate | 1991 |
| record_format | dspace |
| spelling | oxford-uuid:55c63f3a-4aec-425b-9527-b5b20541a1ab2022-03-26T16:46:11ZFactors controlling fat mobilization from human subcutaneous adipose tissue during exercise.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:55c63f3a-4aec-425b-9527-b5b20541a1abEnglishSymplectic Elements at Oxford1991Hodgetts, VCoppack, SFrayn, KHockaday, TTo investigate possible factors that limit fat utilization during exercise, arteriovenous differences of plasma nonesterified fatty acids (NEFA) and glycerol were measured across the subcutaneous adipose tissue of the anterior abdominal wall in nine subjects who exercised for 60 min at 50-70% of their maximal O2 consumption. The large gradient of NEFA concentration from adipose tissue venous to arterial plasma increased throughout the exercise period. Maximal plasma NEFA concentrations in adipose venous drainage were reached postexercise (median 3,800 mumol/l), with a median NEFA-to-albumin molar ratio of 5.7. Fractional reesterification of fatty acids within the tissue (assessed from the ratio of NEFA to glycerol release) was 20-30% in the basal state and declined during exercise. After exercise there was apparently negative reesterification, implying release of NEFA retained in adipose tissue during exercise. Although these findings challenge current views on the regulation of NEFA release, they are in agreement with the concept of supply of fatty acids from adipose tissue as the major factor limiting fat oxidation during sustained exercise. |
| spellingShingle | Hodgetts, V Coppack, S Frayn, K Hockaday, T Factors controlling fat mobilization from human subcutaneous adipose tissue during exercise. |
| title | Factors controlling fat mobilization from human subcutaneous adipose tissue during exercise. |
| title_full | Factors controlling fat mobilization from human subcutaneous adipose tissue during exercise. |
| title_fullStr | Factors controlling fat mobilization from human subcutaneous adipose tissue during exercise. |
| title_full_unstemmed | Factors controlling fat mobilization from human subcutaneous adipose tissue during exercise. |
| title_short | Factors controlling fat mobilization from human subcutaneous adipose tissue during exercise. |
| title_sort | factors controlling fat mobilization from human subcutaneous adipose tissue during exercise |
| work_keys_str_mv | AT hodgettsv factorscontrollingfatmobilizationfromhumansubcutaneousadiposetissueduringexercise AT coppacks factorscontrollingfatmobilizationfromhumansubcutaneousadiposetissueduringexercise AT fraynk factorscontrollingfatmobilizationfromhumansubcutaneousadiposetissueduringexercise AT hockadayt factorscontrollingfatmobilizationfromhumansubcutaneousadiposetissueduringexercise |