Evaluating the fat distribution in idiopathic intracranial hypertension using dual-energy X-ray absorptiometry scanning
Idiopathic intracranial hypertension (IIH) is strongly associated with obesity. We aimed to utilise dual-energy X-ray absorptiometry (DEXA) to characterise fat distribution, and to evaluate change in fat mass and distribution following weight loss. IIH patients (n = 24) had a similar fat distributio...
| Main Authors: | , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Taylor and Francis
2017
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| _version_ | 1826273117316579328 |
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| author | Hornby, C Botfield, H O'Reilly, M Westgate, C Mitchell, J Mollan, S Manolopoulos, K Tomlinson, J Sinclair, A |
| author_facet | Hornby, C Botfield, H O'Reilly, M Westgate, C Mitchell, J Mollan, S Manolopoulos, K Tomlinson, J Sinclair, A |
| author_sort | Hornby, C |
| collection | OXFORD |
| description | Idiopathic intracranial hypertension (IIH) is strongly associated with obesity. We aimed to utilise dual-energy X-ray absorptiometry (DEXA) to characterise fat distribution, and to evaluate change in fat mass and distribution following weight loss. IIH patients (n = 24) had a similar fat distribution to body mass index (BMI)- and gender-matched obese controls (n = 47). In the IIH cohort, truncal fat mass correlated with lumbar puncture pressure. Weight loss in IIH patients resulted in a significant reduction in disease activity and fat mass, predominantly from the truncal region (-4.40 ± 1.6%; p = 0.008) compared with the limbs (+0.79 ± 6.5%; p = 0.71). These results indicate that, contrary to previous studies using waist-hip ratios, IIH adiposity is centripetal, similar to simple obesity. Future studies should establish the risk of the metabolic syndrome and the role of adipose tissue depot-specific function in IIH. |
| first_indexed | 2024-03-06T22:23:18Z |
| format | Journal article |
| id | oxford-uuid:55cb5981-29a8-438c-ac8c-f2bb34bb0a5c |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:23:18Z |
| publishDate | 2017 |
| publisher | Taylor and Francis |
| record_format | dspace |
| spelling | oxford-uuid:55cb5981-29a8-438c-ac8c-f2bb34bb0a5c2022-03-26T16:46:25ZEvaluating the fat distribution in idiopathic intracranial hypertension using dual-energy X-ray absorptiometry scanningJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:55cb5981-29a8-438c-ac8c-f2bb34bb0a5cEnglishSymplectic Elements at OxfordTaylor and Francis2017Hornby, CBotfield, HO'Reilly, MWestgate, CMitchell, JMollan, SManolopoulos, KTomlinson, JSinclair, AIdiopathic intracranial hypertension (IIH) is strongly associated with obesity. We aimed to utilise dual-energy X-ray absorptiometry (DEXA) to characterise fat distribution, and to evaluate change in fat mass and distribution following weight loss. IIH patients (n = 24) had a similar fat distribution to body mass index (BMI)- and gender-matched obese controls (n = 47). In the IIH cohort, truncal fat mass correlated with lumbar puncture pressure. Weight loss in IIH patients resulted in a significant reduction in disease activity and fat mass, predominantly from the truncal region (-4.40 ± 1.6%; p = 0.008) compared with the limbs (+0.79 ± 6.5%; p = 0.71). These results indicate that, contrary to previous studies using waist-hip ratios, IIH adiposity is centripetal, similar to simple obesity. Future studies should establish the risk of the metabolic syndrome and the role of adipose tissue depot-specific function in IIH. |
| spellingShingle | Hornby, C Botfield, H O'Reilly, M Westgate, C Mitchell, J Mollan, S Manolopoulos, K Tomlinson, J Sinclair, A Evaluating the fat distribution in idiopathic intracranial hypertension using dual-energy X-ray absorptiometry scanning |
| title | Evaluating the fat distribution in idiopathic intracranial hypertension using dual-energy X-ray absorptiometry scanning |
| title_full | Evaluating the fat distribution in idiopathic intracranial hypertension using dual-energy X-ray absorptiometry scanning |
| title_fullStr | Evaluating the fat distribution in idiopathic intracranial hypertension using dual-energy X-ray absorptiometry scanning |
| title_full_unstemmed | Evaluating the fat distribution in idiopathic intracranial hypertension using dual-energy X-ray absorptiometry scanning |
| title_short | Evaluating the fat distribution in idiopathic intracranial hypertension using dual-energy X-ray absorptiometry scanning |
| title_sort | evaluating the fat distribution in idiopathic intracranial hypertension using dual energy x ray absorptiometry scanning |
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