The generation of a simian adenoviral vectored HCV vaccine encoding genetically conserved gene segments to target multiple HCV genotypes

The generation of a simian adenoviral vectored HCV vaccine encoding genetically conserved gene segments to target multiple HCV genotypes

Hepatitis C virus (HCV) genomic variability is a major challenge to the generation of a prophylactic vaccine. We have previously shown that HCV specific T-cell responses induced by a potent T-cell vaccine encoding a single strain subtype-1b immunogen target epitopes dominant in natural infection. Ho...

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Bibliographic Details
Main Authors: von Delft, A, Donnison, T, Lourenço, J, Hutchings, C, Mullarkey, C, Brown, A, Pybus, O, Klenerman, P, Chinnakannan, S, Barnes, E
Format: Journal article
Language:English
Published: Elsevier 2017

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