Warming alters life-history traits and competition in a phage community
Host-parasite interactions are highly susceptible to changes in temperature due to mismatches in species thermal responses. In nature, parasites often exist in communities, and responses to temperature are expected to vary between host-parasite pairs. Temperature change thus has consequences for bot...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
American Society for Microbiology
2024
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| _version_ | 1811139374667005952 |
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| author | Greenrod, STE Cazares Lopez, D Johnson, S Hector, T Stevens, E Maclean, C King, K |
| author_facet | Greenrod, STE Cazares Lopez, D Johnson, S Hector, T Stevens, E Maclean, C King, K |
| author_sort | Greenrod, STE |
| collection | OXFORD |
| description | Host-parasite interactions are highly susceptible to changes in temperature due to mismatches in
species thermal responses. In nature, parasites often exist in communities, and responses to
temperature are expected to vary between host-parasite pairs. Temperature change thus has
consequences for both host-parasite dynamics and parasite-parasite interactions. Here, we
investigate the impact of warming (37°C, 40°C, 42°C) on parasite life-history traits and competition
using the opportunistic bacterial pathogen Pseudomonas aeruginosa (host) and a panel of three
genetically diverse lytic bacteriophages (parasites). We show that phages vary in their responses to
temperature; while 37°C and 40°C did not have a major effect on phage infectivity, infection by two
phage was restricted at 42°C. This outcome was attributed to disruption of different phage lifehistory traits including host attachment and replication inside hosts. Further, we show that
temperature mediates competition between phages by altering their competitiveness. These results
highlight phage trait variation across thermal regimes with the potential to drive community
dynamics. Our results have important implications for eukaryotic viromes and the design of phage
cocktail therapies. |
| first_indexed | 2024-04-09T03:57:45Z |
| format | Journal article |
| id | oxford-uuid:55fb5b0a-635a-473b-bcb6-abb16439742a |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-09-25T04:05:05Z |
| publishDate | 2024 |
| publisher | American Society for Microbiology |
| record_format | dspace |
| spelling | oxford-uuid:55fb5b0a-635a-473b-bcb6-abb16439742a2024-05-29T10:34:29ZWarming alters life-history traits and competition in a phage communityJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:55fb5b0a-635a-473b-bcb6-abb16439742aEnglishSymplectic ElementsAmerican Society for Microbiology2024Greenrod, STECazares Lopez, DJohnson, SHector, TStevens, EMaclean, CKing, KHost-parasite interactions are highly susceptible to changes in temperature due to mismatches in species thermal responses. In nature, parasites often exist in communities, and responses to temperature are expected to vary between host-parasite pairs. Temperature change thus has consequences for both host-parasite dynamics and parasite-parasite interactions. Here, we investigate the impact of warming (37°C, 40°C, 42°C) on parasite life-history traits and competition using the opportunistic bacterial pathogen Pseudomonas aeruginosa (host) and a panel of three genetically diverse lytic bacteriophages (parasites). We show that phages vary in their responses to temperature; while 37°C and 40°C did not have a major effect on phage infectivity, infection by two phage was restricted at 42°C. This outcome was attributed to disruption of different phage lifehistory traits including host attachment and replication inside hosts. Further, we show that temperature mediates competition between phages by altering their competitiveness. These results highlight phage trait variation across thermal regimes with the potential to drive community dynamics. Our results have important implications for eukaryotic viromes and the design of phage cocktail therapies. |
| spellingShingle | Greenrod, STE Cazares Lopez, D Johnson, S Hector, T Stevens, E Maclean, C King, K Warming alters life-history traits and competition in a phage community |
| title | Warming alters life-history traits and competition in a phage community |
| title_full | Warming alters life-history traits and competition in a phage community |
| title_fullStr | Warming alters life-history traits and competition in a phage community |
| title_full_unstemmed | Warming alters life-history traits and competition in a phage community |
| title_short | Warming alters life-history traits and competition in a phage community |
| title_sort | warming alters life history traits and competition in a phage community |
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