Multiple myeloma metabolism – a treasure trove of therapeutic targets?
Multiple myeloma is an incurable cancer of plasma cells that is predominantly located in the bone marrow. Multiple myeloma cells are characterized by distinctive biological features that are intricately linked to their core function, the assembly and secretion of large amounts of antibodies, and the...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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Frontiers Media
2022
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| _version_ | 1797107951482175488 |
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| author | Roman-Trufero, M Auner, HW Edwards, CM |
| author_facet | Roman-Trufero, M Auner, HW Edwards, CM |
| author_sort | Roman-Trufero, M |
| collection | OXFORD |
| description | Multiple myeloma is an incurable cancer of plasma cells that is predominantly located in the bone marrow. Multiple myeloma cells are characterized by distinctive biological features that are intricately linked to their core function, the assembly and secretion of large amounts of antibodies, and their diverse interactions with the bone marrow microenvironment. Here, we provide a concise and introductory discussion of major metabolic hallmarks of plasma cells and myeloma cells, their roles in myeloma development and progression, and how they could be exploited for therapeutic purposes. We review the role of glucose consumption and catabolism, assess the dependency on glutamine to support key metabolic processes, and consider metabolic adaptations in drug-resistant myeloma cells. Finally, we examine the complex metabolic effects of proteasome inhibitors on myeloma cells and the extracellular matrix, and we explore the complex relationship between myeloma cells and bone marrow adipocytes. |
| first_indexed | 2024-03-07T07:22:44Z |
| format | Journal article |
| id | oxford-uuid:5600fa22-1583-4731-8e21-377dba557a82 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T07:22:44Z |
| publishDate | 2022 |
| publisher | Frontiers Media |
| record_format | dspace |
| spelling | oxford-uuid:5600fa22-1583-4731-8e21-377dba557a822022-10-25T10:33:00ZMultiple myeloma metabolism – a treasure trove of therapeutic targets?Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:5600fa22-1583-4731-8e21-377dba557a82EnglishSymplectic ElementsFrontiers Media2022Roman-Trufero, MAuner, HWEdwards, CMMultiple myeloma is an incurable cancer of plasma cells that is predominantly located in the bone marrow. Multiple myeloma cells are characterized by distinctive biological features that are intricately linked to their core function, the assembly and secretion of large amounts of antibodies, and their diverse interactions with the bone marrow microenvironment. Here, we provide a concise and introductory discussion of major metabolic hallmarks of plasma cells and myeloma cells, their roles in myeloma development and progression, and how they could be exploited for therapeutic purposes. We review the role of glucose consumption and catabolism, assess the dependency on glutamine to support key metabolic processes, and consider metabolic adaptations in drug-resistant myeloma cells. Finally, we examine the complex metabolic effects of proteasome inhibitors on myeloma cells and the extracellular matrix, and we explore the complex relationship between myeloma cells and bone marrow adipocytes. |
| spellingShingle | Roman-Trufero, M Auner, HW Edwards, CM Multiple myeloma metabolism – a treasure trove of therapeutic targets? |
| title | Multiple myeloma metabolism – a treasure trove of therapeutic targets? |
| title_full | Multiple myeloma metabolism – a treasure trove of therapeutic targets? |
| title_fullStr | Multiple myeloma metabolism – a treasure trove of therapeutic targets? |
| title_full_unstemmed | Multiple myeloma metabolism – a treasure trove of therapeutic targets? |
| title_short | Multiple myeloma metabolism – a treasure trove of therapeutic targets? |
| title_sort | multiple myeloma metabolism a treasure trove of therapeutic targets |
| work_keys_str_mv | AT romantruferom multiplemyelomametabolismatreasuretroveoftherapeutictargets AT aunerhw multiplemyelomametabolismatreasuretroveoftherapeutictargets AT edwardscm multiplemyelomametabolismatreasuretroveoftherapeutictargets |