MAPT genetic variation and neuronal maturity alter isoform expression affecting axonal transport in iPSC-derived dopamine neurons.

MAPT genetic variation and neuronal maturity alter isoform expression affecting axonal transport in iPSC-derived dopamine neurons.

The H1 haplotype of the microtubule-associated protein tau (MAPT) locus is genetically associated with neurodegenerative diseases, including Parkinson's disease (PD), and affects gene expression and splicing. However, the functional impact on neurons of such expression differences has yet to be...

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Dades bibliogràfiques
Autors principals:	Beevers, J, Lai, M, Collins, E, Booth, H, Zambon, F, Parkkinen, L, Vowles, J, Cowley, S, Wade-Martins, R, Caffrey, T
Format:	Journal article
Idioma:	English
Publicat:	Elsevier 2017

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