MAPT genetic variation and neuronal maturity alter isoform expression affecting axonal transport in iPSC-derived dopamine neurons.

MAPT genetic variation and neuronal maturity alter isoform expression affecting axonal transport in iPSC-derived dopamine neurons.

The H1 haplotype of the microtubule-associated protein tau (MAPT) locus is genetically associated with neurodegenerative diseases, including Parkinson's disease (PD), and affects gene expression and splicing. However, the functional impact on neurons of such expression differences has yet to be...

书目详细资料
Main Authors:	Beevers, J, Lai, M, Collins, E, Booth, H, Zambon, F, Parkkinen, L, Vowles, J, Cowley, S, Wade-Martins, R, Caffrey, T
格式:	Journal article
语言:	English
出版:	Elsevier 2017

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