Assessing the role of ADAM10 in Trastuzumab treatment and resistance

Assessing the role of ADAM10 in Trastuzumab treatment and resistance

<p>Overexpression of the HER2 receptor occurs in about 15-20% of all breast cancers and is correlated with poor prognosis. Trastuzumab (Herceptin®), a monoclonal antibody targeting HER2, was shown to prolong survival of these patients. However, primary or acquired resistance remains a drawback...

Descripció completa

Dades bibliogràfiques
Autor principal:	Feldinger, K
Altres autors:	Kong, A
Format:	Thesis
Idioma:	English
Publicat:	2012
Matèries:	Cell Biology (see also Plant sciences) Oncology Biology

Ítems similars

Functional organisation of the Hrd1 ubiquitin ligase complex and its role in ERAD
per: Schulz, J
Publicat: (2013)

The role and regulation of Asterless in the centrosome cycle
per: Novak, ZA
Publicat: (2014)

Characterisation of AEBP2: a polycomb repressive complex 2 component
per: Grijzenhout, A
Publicat: (2013)

Cell stress response and hypoxia in breast cancer
per: Milani, M, et al.
Publicat: (2011)

Nitric oxide: a chemical effector of pathogenesis in magnaporthe oryzae
per: Johnson, J
Publicat: (2011)

The role of protein kinase C in platelet activation
per: Unsworth, AJ
Publicat: (2012)

The role of Adaptor Protein 3 in cytotoxic T lymphocytes
per: Wenham, M
Publicat: (2009)

Regulation of E2F-1 by methylation and NEDDylation
per: Loftus, S, et al.
Publicat: (2012)

Heterogeneity of tumour response to hypoxia: carbonic anhydrase IX induction defines a subpopulation of hypoxic cells with stem cell properties and drug resistance
per: Ledaki, I
Publicat: (2013)

Functions of conserved centriole proteins in African trypanosomes
per: Scheumann, N
Publicat: (2012)

Towards understanding the mechanism of cohesin loading
per: Dixon, SE
Publicat: (2013)

E2F7: a member of the E2F family with a novel mechanism of transcriptional repression
per: Kesoglidou, PX
Publicat: (2012)

Factors contributing to chondroplasia in degenerate rotator cuff disease
per: Cornell, HR
Publicat: (2011)

Targeting cell adhesion as a method of sensitising metastatic tumour cells to TRAIL-induced apoptosis
per: Phipps, L
Publicat: (2011)

Determining the mechanism of pathogenesis of mucolipidosis type IV and related lysosomal storage disorders for development of novel therapies
per: Peterneva, K
Publicat: (2014)

Investigating the function of Drosophila MAPs Msd1 and dTD-60 in mitotic spindle assembly
per: Duncan, T
Publicat: (2011)

Design, implementation and experimental validation of a network-based model to predict mitotic microtubule regulating proteins
per: Khan, FF
Publicat: (2013)

Deconstructing the trypanosome cytoskeleton: from structures to functions via components and complexes.
per: Portman, N
Publicat: (2011)

Structure-function studies of fibronectin domains in the human endometrium
per: Mok, M, et al.
Publicat: (2008)

Syncrip regulates mRNA localisation and translation at the drosophila neuromuscular junction
per: Halstead, J
Publicat: (2013)

Studies on HIF hydroxylases
per: Webb, J
Publicat: (2008)

Hypoxia-inducible factor is expressed in giant cell tumour of bone and mediates paracrine effects of hypoxia on monocyte-osteoclast differentiation via induction of VEGF
per: Knowles, H, et al.
Publicat: (2008)

Functional analysis of cancer/testis antigens in human cancer
per: Pagotto, A
Publicat: (2013)

Human orthologues of Saccharomyces cerevisiae Trf4/5 non-canonical poly(A) polymerases
per: Gibson, K
Publicat: (2011)

The influence of BRCA1's ubiquitin ligase activity on cell motility
per: Sengupta, S
Publicat: (2014)

Regulation and reproductive functions of membrane-bound vesicles secreted by the Drosophila male accessory gland
per: Corrigan, L
Publicat: (2014)

The evolution of eukaryotic cilia
per: Hodges, M, et al.
Publicat: (2011)

The role of autophagy in CD8+ T cell immunity
per: Puleston, D, et al.
Publicat: (2015)

Wac: a new Augmin subunit required for chromosome alignment but not for acentrosomal microtubule assembly in female meiosis
per: Meireles, A, et al.
Publicat: (2009)

The relation between multilocus population genetics and social evolution theory
per: Gardner, A, et al.
Publicat: (2007)

Cellular models for characterisation of MINA53, a 2-oxoglutarate-dependent dioxygenase
per: Zayer, A
Publicat: (2012)

Vertex model approaches to epithelial tissues in developmental systems
per: Smith, A
Publicat: (2012)

Identification and characterisation of homologous recombination genes in Schizosaccharomyces pombe
per: Moss, J
Publicat: (2011)

Mucosal associated invariant T cells and related CD161 expressing T lymphocytes
per: Fergusson, J, et al.
Publicat: (2015)

Segmentation of cell clumps for quantitative analysis
per: Li, S
Publicat: (2010)

Expression of two-pore channels in mammalian primary cells and tissues, and their role in adipose tissue formation and function
per: Tunn, R
Publicat: (2012)

Elucidating the pathway of centrosome formation
per: Costa Vicente, C
Publicat: (2013)

Automated segmentation and alignment of mitotic nuclei for Kymograph visualisation
per: Li, S, et al.
Publicat: (2011)

The role of p53 in hypoxia-induced apoptosis
per: Poole, R
Publicat: (2010)

Effect of CTCF and Cohesin on the dynamics of RNA polymerase II transcription and coupled pre-messenger RNA processing
per: Liska, O
Publicat: (2013)