Assessing the role of ADAM10 in Trastuzumab treatment and resistance

Assessing the role of ADAM10 in Trastuzumab treatment and resistance

<p>Overexpression of the HER2 receptor occurs in about 15-20% of all breast cancers and is correlated with poor prognosis. Trastuzumab (Herceptin®), a monoclonal antibody targeting HER2, was shown to prolong survival of these patients. However, primary or acquired resistance remains a drawback...

Fuld beskrivelse

Bibliografiske detaljer
Hovedforfatter:	Feldinger, K
Andre forfattere:	Kong, A
Format:	Thesis
Sprog:	English
Udgivet:	2012
Fag:	Cell Biology (see also Plant sciences) Oncology Biology

Lignende værker

Functional organisation of the Hrd1 ubiquitin ligase complex and its role in ERAD
af: Schulz, J
Udgivet: (2013)

The role and regulation of Asterless in the centrosome cycle
af: Novak, ZA
Udgivet: (2014)

Characterisation of AEBP2: a polycomb repressive complex 2 component
af: Grijzenhout, A
Udgivet: (2013)

Cell stress response and hypoxia in breast cancer
af: Milani, M, et al.
Udgivet: (2011)

Nitric oxide: a chemical effector of pathogenesis in magnaporthe oryzae
af: Johnson, J
Udgivet: (2011)

The role of protein kinase C in platelet activation
af: Unsworth, AJ
Udgivet: (2012)

The role of Adaptor Protein 3 in cytotoxic T lymphocytes
af: Wenham, M
Udgivet: (2009)

Regulation of E2F-1 by methylation and NEDDylation
af: Loftus, S, et al.
Udgivet: (2012)

Heterogeneity of tumour response to hypoxia: carbonic anhydrase IX induction defines a subpopulation of hypoxic cells with stem cell properties and drug resistance
af: Ledaki, I
Udgivet: (2013)

Functions of conserved centriole proteins in African trypanosomes
af: Scheumann, N
Udgivet: (2012)

Towards understanding the mechanism of cohesin loading
af: Dixon, SE
Udgivet: (2013)

E2F7: a member of the E2F family with a novel mechanism of transcriptional repression
af: Kesoglidou, PX
Udgivet: (2012)

Factors contributing to chondroplasia in degenerate rotator cuff disease
af: Cornell, HR
Udgivet: (2011)

Targeting cell adhesion as a method of sensitising metastatic tumour cells to TRAIL-induced apoptosis
af: Phipps, L
Udgivet: (2011)

Determining the mechanism of pathogenesis of mucolipidosis type IV and related lysosomal storage disorders for development of novel therapies
af: Peterneva, K
Udgivet: (2014)

Investigating the function of Drosophila MAPs Msd1 and dTD-60 in mitotic spindle assembly
af: Duncan, T
Udgivet: (2011)

Design, implementation and experimental validation of a network-based model to predict mitotic microtubule regulating proteins
af: Khan, FF
Udgivet: (2013)

Deconstructing the trypanosome cytoskeleton: from structures to functions via components and complexes.
af: Portman, N
Udgivet: (2011)

Structure-function studies of fibronectin domains in the human endometrium
af: Mok, M, et al.
Udgivet: (2008)

Syncrip regulates mRNA localisation and translation at the drosophila neuromuscular junction
af: Halstead, J
Udgivet: (2013)

Studies on HIF hydroxylases
af: Webb, J
Udgivet: (2008)

Hypoxia-inducible factor is expressed in giant cell tumour of bone and mediates paracrine effects of hypoxia on monocyte-osteoclast differentiation via induction of VEGF
af: Knowles, H, et al.
Udgivet: (2008)

Functional analysis of cancer/testis antigens in human cancer
af: Pagotto, A
Udgivet: (2013)

Human orthologues of Saccharomyces cerevisiae Trf4/5 non-canonical poly(A) polymerases
af: Gibson, K
Udgivet: (2011)

The influence of BRCA1's ubiquitin ligase activity on cell motility
af: Sengupta, S
Udgivet: (2014)

Regulation and reproductive functions of membrane-bound vesicles secreted by the Drosophila male accessory gland
af: Corrigan, L
Udgivet: (2014)

The evolution of eukaryotic cilia
af: Hodges, M, et al.
Udgivet: (2011)

The role of autophagy in CD8+ T cell immunity
af: Puleston, D, et al.
Udgivet: (2015)

Wac: a new Augmin subunit required for chromosome alignment but not for acentrosomal microtubule assembly in female meiosis
af: Meireles, A, et al.
Udgivet: (2009)

The relation between multilocus population genetics and social evolution theory
af: Gardner, A, et al.
Udgivet: (2007)

Cellular models for characterisation of MINA53, a 2-oxoglutarate-dependent dioxygenase
af: Zayer, A
Udgivet: (2012)

Vertex model approaches to epithelial tissues in developmental systems
af: Smith, A
Udgivet: (2012)

Identification and characterisation of homologous recombination genes in Schizosaccharomyces pombe
af: Moss, J
Udgivet: (2011)

Mucosal associated invariant T cells and related CD161 expressing T lymphocytes
af: Fergusson, J, et al.
Udgivet: (2015)

Segmentation of cell clumps for quantitative analysis
af: Li, S
Udgivet: (2010)

Expression of two-pore channels in mammalian primary cells and tissues, and their role in adipose tissue formation and function
af: Tunn, R
Udgivet: (2012)

Elucidating the pathway of centrosome formation
af: Costa Vicente, C
Udgivet: (2013)

Automated segmentation and alignment of mitotic nuclei for Kymograph visualisation
af: Li, S, et al.
Udgivet: (2011)

The role of p53 in hypoxia-induced apoptosis
af: Poole, R
Udgivet: (2010)

Effect of CTCF and Cohesin on the dynamics of RNA polymerase II transcription and coupled pre-messenger RNA processing
af: Liska, O
Udgivet: (2013)