Assessing the role of ADAM10 in Trastuzumab treatment and resistance
<p>Overexpression of the HER2 receptor occurs in about 15-20% of all breast cancers and is correlated with poor prognosis. Trastuzumab (Herceptin®), a monoclonal antibody targeting HER2, was shown to prolong survival of these patients. However, primary or acquired resistance remains a drawback...
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| 格式: | Thesis |
| 語言: | English |
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2012
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