Four base recognition by triplex-forming oligonucleotides at physiological pH.

We have achieved recognition of all 4 bp by triple helix formation at physiological pH, using triplex-forming oligonucleotides that contain four different synthetic nucleotides. BAU [2'-aminoethoxy-5-(3-aminoprop-1-ynyl)uridine] recognizes AT base pairs with high affinity, (Me)P (3-methyl-2 ami...

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Bibliografiske detaljer
Main Authors: Rusling, D, Powers, V, Ranasinghe, RT, Wang, Y, Osborne, S, Brown, T, Fox, K
Format: Journal article
Sprog:English
Udgivet: 2005