Transient increase of interferon-stimulated genes and no clinical benefit by chloroquine treatment during acute simian immunodeficiency virus infection of macaques.

Simian immunodeficiency virus (SIV) infection leads to AIDS in experimentally infected Rhesus macaques similarly to HIV-infected humans. In contrast, SIV infection of natural hosts is characterized by a down-regulation of innate acute responses to the virus within a few weeks of infection and result...

पूर्ण विवरण

ग्रंथसूची विवरण
मुख्य लेखकों: Vaccari, M, Fenizia, C, Ma, Z, Hryniewicz, A, Boasso, A, Doster, M, Miller, C, Lindegardh, N, Tarning, J, Landay, A, Shearer, G, Franchini, G
स्वरूप: Journal article
भाषा:English
प्रकाशित: Mary Ann Liebert Inc. 2014
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author Vaccari, M
Fenizia, C
Ma, Z
Hryniewicz, A
Boasso, A
Doster, M
Miller, C
Lindegardh, N
Tarning, J
Landay, A
Shearer, G
Franchini, G
author_facet Vaccari, M
Fenizia, C
Ma, Z
Hryniewicz, A
Boasso, A
Doster, M
Miller, C
Lindegardh, N
Tarning, J
Landay, A
Shearer, G
Franchini, G
author_sort Vaccari, M
collection OXFORD
description Simian immunodeficiency virus (SIV) infection leads to AIDS in experimentally infected Rhesus macaques similarly to HIV-infected humans. In contrast, SIV infection of natural hosts is characterized by a down-regulation of innate acute responses to the virus within a few weeks of infection and results in limited pathology. Chloroquine (CQ) has been used in the treatment or prevention of malaria and has recently been shown to cause a decrease of immune activation and CD4 cell loss in HIV-infected individuals treated with antiretroviral therapy. Here, we treated Rhesus macaques with CQ during the acute phase of SIVmac251 infection with the intent to decrease viral-induced immune activation and possibly limit disease progression. Contrary to what was expected, CQ treatment resulted in a temporary increased expression of interferon (IFN)-stimulating genes and it worsened the recovery of CD4(+) T cells in the blood. Our findings confirm recent results observed in asymptomatic HIV-infected patients and suggest that CQ does not provide an obvious benefit in the absence of antiretroviral therapy.
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spelling oxford-uuid:5676cfcc-c2c4-428f-af8c-2daa51a184052022-03-26T16:50:24ZTransient increase of interferon-stimulated genes and no clinical benefit by chloroquine treatment during acute simian immunodeficiency virus infection of macaques.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:5676cfcc-c2c4-428f-af8c-2daa51a18405EnglishSymplectic Elements at OxfordMary Ann Liebert Inc.2014Vaccari, MFenizia, CMa, ZHryniewicz, ABoasso, ADoster, MMiller, CLindegardh, NTarning, JLanday, AShearer, GFranchini, GSimian immunodeficiency virus (SIV) infection leads to AIDS in experimentally infected Rhesus macaques similarly to HIV-infected humans. In contrast, SIV infection of natural hosts is characterized by a down-regulation of innate acute responses to the virus within a few weeks of infection and results in limited pathology. Chloroquine (CQ) has been used in the treatment or prevention of malaria and has recently been shown to cause a decrease of immune activation and CD4 cell loss in HIV-infected individuals treated with antiretroviral therapy. Here, we treated Rhesus macaques with CQ during the acute phase of SIVmac251 infection with the intent to decrease viral-induced immune activation and possibly limit disease progression. Contrary to what was expected, CQ treatment resulted in a temporary increased expression of interferon (IFN)-stimulating genes and it worsened the recovery of CD4(+) T cells in the blood. Our findings confirm recent results observed in asymptomatic HIV-infected patients and suggest that CQ does not provide an obvious benefit in the absence of antiretroviral therapy.
spellingShingle Vaccari, M
Fenizia, C
Ma, Z
Hryniewicz, A
Boasso, A
Doster, M
Miller, C
Lindegardh, N
Tarning, J
Landay, A
Shearer, G
Franchini, G
Transient increase of interferon-stimulated genes and no clinical benefit by chloroquine treatment during acute simian immunodeficiency virus infection of macaques.
title Transient increase of interferon-stimulated genes and no clinical benefit by chloroquine treatment during acute simian immunodeficiency virus infection of macaques.
title_full Transient increase of interferon-stimulated genes and no clinical benefit by chloroquine treatment during acute simian immunodeficiency virus infection of macaques.
title_fullStr Transient increase of interferon-stimulated genes and no clinical benefit by chloroquine treatment during acute simian immunodeficiency virus infection of macaques.
title_full_unstemmed Transient increase of interferon-stimulated genes and no clinical benefit by chloroquine treatment during acute simian immunodeficiency virus infection of macaques.
title_short Transient increase of interferon-stimulated genes and no clinical benefit by chloroquine treatment during acute simian immunodeficiency virus infection of macaques.
title_sort transient increase of interferon stimulated genes and no clinical benefit by chloroquine treatment during acute simian immunodeficiency virus infection of macaques
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