Clinical Manifestations and Molecular Diagnosis of Scrub Typhus and Murine Typhus, Vietnam, 2015–2017
Rickettsioses are endemic to Vietnam; however, only a limited number of clinical studies have been performed on these vectorborne bacteria. We conducted a prospective hospital-based study at 2 national referral hospitals in Hanoi to describe the clinical characteristics of scrub typhus and murine ty...
| Hoofdauteurs: | , , , , , , , , , , , , , |
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| Formaat: | Journal article |
| Taal: | English |
| Gepubliceerd in: |
Centers for Disease Control and Prevention
2019
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| _version_ | 1826273271769726976 |
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| author | Trung, NV Hoi, LT Dien, VM Huong, DT Hoa, TM Lien, VN Van Luan, P Lewycka, SO Choisy, M Bryant, JE Nadjm, B van Doorn, H Richards, AL Van Kinh, N |
| author_facet | Trung, NV Hoi, LT Dien, VM Huong, DT Hoa, TM Lien, VN Van Luan, P Lewycka, SO Choisy, M Bryant, JE Nadjm, B van Doorn, H Richards, AL Van Kinh, N |
| author_sort | Trung, NV |
| collection | OXFORD |
| description | Rickettsioses are endemic to Vietnam; however, only a limited number of clinical studies have been performed on these vectorborne bacteria. We conducted a prospective hospital-based study at 2 national referral hospitals in Hanoi to describe the clinical characteristics of scrub typhus and murine typhus in northern Vietnam and to assess the diagnostic applicability of quantitative real-time PCR assays to diagnose rickettsial diseases. We enrolled 302 patients with acute undifferentiated fever and clinically suspected rickettsiosis during March 2015-March 2017. We used a standardized case report form to collect clinical information and laboratory results at the time of admission and during treatment. We confirmed scrub typhus in 103 (34.1%) patients and murine typhus in 12 (3.3%) patients. These results highlight the need for increased emphasis on training for healthcare providers for earlier recognition, prevention, and treatment of rickettsial diseases in Vietnam. |
| first_indexed | 2024-03-06T22:25:40Z |
| format | Journal article |
| id | oxford-uuid:56978f12-090c-4ed2-b0ef-e824e7e6acf1 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:25:40Z |
| publishDate | 2019 |
| publisher | Centers for Disease Control and Prevention |
| record_format | dspace |
| spelling | oxford-uuid:56978f12-090c-4ed2-b0ef-e824e7e6acf12022-03-26T16:51:12ZClinical Manifestations and Molecular Diagnosis of Scrub Typhus and Murine Typhus, Vietnam, 2015–2017Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:56978f12-090c-4ed2-b0ef-e824e7e6acf1EnglishSymplectic Elements at OxfordCenters for Disease Control and Prevention2019Trung, NVHoi, LTDien, VMHuong, DTHoa, TMLien, VNVan Luan, PLewycka, SOChoisy, MBryant, JENadjm, Bvan Doorn, HRichards, ALVan Kinh, NRickettsioses are endemic to Vietnam; however, only a limited number of clinical studies have been performed on these vectorborne bacteria. We conducted a prospective hospital-based study at 2 national referral hospitals in Hanoi to describe the clinical characteristics of scrub typhus and murine typhus in northern Vietnam and to assess the diagnostic applicability of quantitative real-time PCR assays to diagnose rickettsial diseases. We enrolled 302 patients with acute undifferentiated fever and clinically suspected rickettsiosis during March 2015-March 2017. We used a standardized case report form to collect clinical information and laboratory results at the time of admission and during treatment. We confirmed scrub typhus in 103 (34.1%) patients and murine typhus in 12 (3.3%) patients. These results highlight the need for increased emphasis on training for healthcare providers for earlier recognition, prevention, and treatment of rickettsial diseases in Vietnam. |
| spellingShingle | Trung, NV Hoi, LT Dien, VM Huong, DT Hoa, TM Lien, VN Van Luan, P Lewycka, SO Choisy, M Bryant, JE Nadjm, B van Doorn, H Richards, AL Van Kinh, N Clinical Manifestations and Molecular Diagnosis of Scrub Typhus and Murine Typhus, Vietnam, 2015–2017 |
| title | Clinical Manifestations and Molecular Diagnosis of Scrub Typhus and Murine Typhus, Vietnam, 2015–2017 |
| title_full | Clinical Manifestations and Molecular Diagnosis of Scrub Typhus and Murine Typhus, Vietnam, 2015–2017 |
| title_fullStr | Clinical Manifestations and Molecular Diagnosis of Scrub Typhus and Murine Typhus, Vietnam, 2015–2017 |
| title_full_unstemmed | Clinical Manifestations and Molecular Diagnosis of Scrub Typhus and Murine Typhus, Vietnam, 2015–2017 |
| title_short | Clinical Manifestations and Molecular Diagnosis of Scrub Typhus and Murine Typhus, Vietnam, 2015–2017 |
| title_sort | clinical manifestations and molecular diagnosis of scrub typhus and murine typhus vietnam 2015 2017 |
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