Brain care score and neuroimaging markers of brain health in asymptomatic middle-age persons
<p><strong>Objectives:</strong> To investigate associations between health-related behaviors as measured using the Brain Care Score (BCS) and neuroimaging markers of white matter injury.</p> <br> <p><strong>Methods:</strong> This prospective cohort stu...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
American Academy of Neurology
2024
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| _version_ | 1811140235407392768 |
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| author | Rivier, CA Singh, S Senff, J Tack, RW Marini, S Clocchiatti-Tuozzo, S Huo, S Renedo, D Papier, K Conroy, M Littlejohns, TJ Chemali, Z Kourkoulis, C Payabvash, S Newhouse, A Westover, MB Lazar, RM Pikula, A Ibrahim, S Howard, VJ Howard, G Brouwers, HB Van Duijn, CM Fricchione, G Tanzi, RE Yechoor, N Sheth, KN Anderson, CD Rosand, J Falcone, GJ |
| author_facet | Rivier, CA Singh, S Senff, J Tack, RW Marini, S Clocchiatti-Tuozzo, S Huo, S Renedo, D Papier, K Conroy, M Littlejohns, TJ Chemali, Z Kourkoulis, C Payabvash, S Newhouse, A Westover, MB Lazar, RM Pikula, A Ibrahim, S Howard, VJ Howard, G Brouwers, HB Van Duijn, CM Fricchione, G Tanzi, RE Yechoor, N Sheth, KN Anderson, CD Rosand, J Falcone, GJ |
| author_sort | Rivier, CA |
| collection | OXFORD |
| description | <p><strong>Objectives:</strong> To investigate associations between health-related behaviors as measured using the Brain Care Score (BCS) and neuroimaging markers of white matter injury.</p>
<br>
<p><strong>Methods:</strong> This prospective cohort study in the UK Biobank assessed the BCS, a novel tool designed to empower patients to address 12 dementia and stroke risk factors. The BCS ranges from 0 to 21, with higher scores suggesting better brain care. Outcomes included white matter hyperintensities (WMH) volume, fractional anisotropy (FA), and mean diffusivity (MD) obtained during 2 imaging assessments, as well as their progression between assessments, using multivariable linear regression adjusted for age and sex.</p>
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<p><strong>Results:</strong> We included 34,509 participants (average age 55 years, 53% female) with no stroke or dementia history. At first and repeat imaging assessments, every 5-point increase in baseline BCS was linked to significantly lower WMH volumes (25% 95% CI [23%–27%] first, 33% [27%–39%] repeat) and higher FA (18% [16%–20%] first, 22% [15%–28%] repeat), with a decrease in MD (9% [7%–11%] first, 10% [4%–16%] repeat). In addition, a higher baseline BCS was associated with a 10% [3%–17%] reduction in WMH progression and FA decline over time.</p>
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<p><strong>Discussion:</strong> This study extends the impact of the BCS to neuroimaging markers of clinically silent cerebrovascular disease. Our results suggest that improving one's BCS could be a valuable intervention to prevent early brain health decline.</p> |
| first_indexed | 2024-09-25T04:18:45Z |
| format | Journal article |
| id | oxford-uuid:5698f840-23f7-4cbe-bbe0-b70119d92302 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-09-25T04:18:45Z |
| publishDate | 2024 |
| publisher | American Academy of Neurology |
| record_format | dspace |
| spelling | oxford-uuid:5698f840-23f7-4cbe-bbe0-b70119d923022024-07-30T15:48:30ZBrain care score and neuroimaging markers of brain health in asymptomatic middle-age personsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:5698f840-23f7-4cbe-bbe0-b70119d92302EnglishSymplectic ElementsAmerican Academy of Neurology2024Rivier, CASingh, SSenff, JTack, RWMarini, SClocchiatti-Tuozzo, SHuo, SRenedo, DPapier, KConroy, MLittlejohns, TJChemali, ZKourkoulis, CPayabvash, SNewhouse, AWestover, MBLazar, RMPikula, AIbrahim, SHoward, VJHoward, GBrouwers, HBVan Duijn, CMFricchione, GTanzi, REYechoor, NSheth, KNAnderson, CDRosand, JFalcone, GJ<p><strong>Objectives:</strong> To investigate associations between health-related behaviors as measured using the Brain Care Score (BCS) and neuroimaging markers of white matter injury.</p> <br> <p><strong>Methods:</strong> This prospective cohort study in the UK Biobank assessed the BCS, a novel tool designed to empower patients to address 12 dementia and stroke risk factors. The BCS ranges from 0 to 21, with higher scores suggesting better brain care. Outcomes included white matter hyperintensities (WMH) volume, fractional anisotropy (FA), and mean diffusivity (MD) obtained during 2 imaging assessments, as well as their progression between assessments, using multivariable linear regression adjusted for age and sex.</p> <br> <p><strong>Results:</strong> We included 34,509 participants (average age 55 years, 53% female) with no stroke or dementia history. At first and repeat imaging assessments, every 5-point increase in baseline BCS was linked to significantly lower WMH volumes (25% 95% CI [23%–27%] first, 33% [27%–39%] repeat) and higher FA (18% [16%–20%] first, 22% [15%–28%] repeat), with a decrease in MD (9% [7%–11%] first, 10% [4%–16%] repeat). In addition, a higher baseline BCS was associated with a 10% [3%–17%] reduction in WMH progression and FA decline over time.</p> <br> <p><strong>Discussion:</strong> This study extends the impact of the BCS to neuroimaging markers of clinically silent cerebrovascular disease. Our results suggest that improving one's BCS could be a valuable intervention to prevent early brain health decline.</p> |
| spellingShingle | Rivier, CA Singh, S Senff, J Tack, RW Marini, S Clocchiatti-Tuozzo, S Huo, S Renedo, D Papier, K Conroy, M Littlejohns, TJ Chemali, Z Kourkoulis, C Payabvash, S Newhouse, A Westover, MB Lazar, RM Pikula, A Ibrahim, S Howard, VJ Howard, G Brouwers, HB Van Duijn, CM Fricchione, G Tanzi, RE Yechoor, N Sheth, KN Anderson, CD Rosand, J Falcone, GJ Brain care score and neuroimaging markers of brain health in asymptomatic middle-age persons |
| title | Brain care score and neuroimaging markers of brain health in asymptomatic middle-age persons |
| title_full | Brain care score and neuroimaging markers of brain health in asymptomatic middle-age persons |
| title_fullStr | Brain care score and neuroimaging markers of brain health in asymptomatic middle-age persons |
| title_full_unstemmed | Brain care score and neuroimaging markers of brain health in asymptomatic middle-age persons |
| title_short | Brain care score and neuroimaging markers of brain health in asymptomatic middle-age persons |
| title_sort | brain care score and neuroimaging markers of brain health in asymptomatic middle age persons |
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