Syndromic and non-syndromic aneurysms of the human ascending aorta share activation of the Smad2 pathway.

Syndromic and non-syndromic aneurysms of the human ascending aorta share activation of the Smad2 pathway.

Common features such as elastic fibre destruction, mucoid accumulation, and smooth muscle cell apoptosis are co-localized in aneurysms of the ascending aorta of various aetiologies. Recent experimental studies reported an activation of TGF-beta in aneurysms related to Marfan (and Loeys-Dietz) syndro...

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Bibliographic Details
Main Authors:	Gomez, D, Zen, A, Borges, L, Philippe, M, Gutierrez, P, Jondeau, G, Michel, J, Vranckx, R
Format:	Journal article
Language:	English
Published:	2009

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