Crystal structures and inhibitor identification for PTPN5, PTPRR and PTPN7: a family of human MAPK-specific protein tyrosine phosphatases.

Crystal structures and inhibitor identification for PTPN5, PTPRR and PTPN7: a family of human MAPK-specific protein tyrosine phosphatases.

Protein tyrosine phosphatases PTPN5, PTPRR and PTPN7 comprise a family of phosphatases that specifically inactivate MAPKs (mitogen-activated protein kinases). We have determined high-resolution structures of all of the human family members, screened them against a library of 24000 compounds and iden...

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Bibliographic Details
Main Authors:	Eswaran, J, von Kries, J, Marsden, B, Longman, E, Debreczeni, J, Ugochukwu, E, Turnbull, A, Lee, W, Knapp, S, Barr, A
Format:	Journal article
Language:	English
Published:	2006

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