Blockade of the AMPA receptor prevents CA1 hippocampal injury following severe but transient forebrain ischemia in adult rats.
The cytoprotective effect of NBQX, a selective AMPA receptor antagonist, was tested following 10 min of severe forebrain ischemia using the 4-vessel occlusion model. Immediately, and at 15 and 30 min following reperfusion, adult Wistar rats received intraperitoneal injections of either saline (n = 5...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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1991
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| _version_ | 1826273311878807552 |
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| author | Buchan, A Li, H Cho, S Pulsinelli, W |
| author_facet | Buchan, A Li, H Cho, S Pulsinelli, W |
| author_sort | Buchan, A |
| collection | OXFORD |
| description | The cytoprotective effect of NBQX, a selective AMPA receptor antagonist, was tested following 10 min of severe forebrain ischemia using the 4-vessel occlusion model. Immediately, and at 15 and 30 min following reperfusion, adult Wistar rats received intraperitoneal injections of either saline (n = 5), 1 mg lithium chloride (n = 17) or 30 mg/kg of the lithium salt of NBQX (n = 18). In saline-treated animals 82 +/- 12% of CA1 hippocampal neurons were lost. Of those treated with lithium 70 +/- 23% were injured, while those given NBQX sustained only 40 +/- 34% CA1 necrosis (P less than 0.01). Twelve of 18 NBQX-treated animals had less than 30% CA1 injury as compared with 1 of 17 lithium-treated animals. The AMPA receptor may play a more important role than the NMDA receptor in selective ischemic necrosis of hippocampal neurons. |
| first_indexed | 2024-03-06T22:26:16Z |
| format | Journal article |
| id | oxford-uuid:56c2ab35-d92e-42e5-ad3f-d1fbe772b2d6 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:26:16Z |
| publishDate | 1991 |
| record_format | dspace |
| spelling | oxford-uuid:56c2ab35-d92e-42e5-ad3f-d1fbe772b2d62022-03-26T16:52:27ZBlockade of the AMPA receptor prevents CA1 hippocampal injury following severe but transient forebrain ischemia in adult rats.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:56c2ab35-d92e-42e5-ad3f-d1fbe772b2d6EnglishSymplectic Elements at Oxford1991Buchan, ALi, HCho, SPulsinelli, WThe cytoprotective effect of NBQX, a selective AMPA receptor antagonist, was tested following 10 min of severe forebrain ischemia using the 4-vessel occlusion model. Immediately, and at 15 and 30 min following reperfusion, adult Wistar rats received intraperitoneal injections of either saline (n = 5), 1 mg lithium chloride (n = 17) or 30 mg/kg of the lithium salt of NBQX (n = 18). In saline-treated animals 82 +/- 12% of CA1 hippocampal neurons were lost. Of those treated with lithium 70 +/- 23% were injured, while those given NBQX sustained only 40 +/- 34% CA1 necrosis (P less than 0.01). Twelve of 18 NBQX-treated animals had less than 30% CA1 injury as compared with 1 of 17 lithium-treated animals. The AMPA receptor may play a more important role than the NMDA receptor in selective ischemic necrosis of hippocampal neurons. |
| spellingShingle | Buchan, A Li, H Cho, S Pulsinelli, W Blockade of the AMPA receptor prevents CA1 hippocampal injury following severe but transient forebrain ischemia in adult rats. |
| title | Blockade of the AMPA receptor prevents CA1 hippocampal injury following severe but transient forebrain ischemia in adult rats. |
| title_full | Blockade of the AMPA receptor prevents CA1 hippocampal injury following severe but transient forebrain ischemia in adult rats. |
| title_fullStr | Blockade of the AMPA receptor prevents CA1 hippocampal injury following severe but transient forebrain ischemia in adult rats. |
| title_full_unstemmed | Blockade of the AMPA receptor prevents CA1 hippocampal injury following severe but transient forebrain ischemia in adult rats. |
| title_short | Blockade of the AMPA receptor prevents CA1 hippocampal injury following severe but transient forebrain ischemia in adult rats. |
| title_sort | blockade of the ampa receptor prevents ca1 hippocampal injury following severe but transient forebrain ischemia in adult rats |
| work_keys_str_mv | AT buchana blockadeoftheampareceptorpreventsca1hippocampalinjuryfollowingseverebuttransientforebrainischemiainadultrats AT lih blockadeoftheampareceptorpreventsca1hippocampalinjuryfollowingseverebuttransientforebrainischemiainadultrats AT chos blockadeoftheampareceptorpreventsca1hippocampalinjuryfollowingseverebuttransientforebrainischemiainadultrats AT pulsinelliw blockadeoftheampareceptorpreventsca1hippocampalinjuryfollowingseverebuttransientforebrainischemiainadultrats |