JNK2 mediates TNF-induced cell death in mouse embryonic fibroblasts via regulation of both caspase and cathepsin protease pathways.

JNK2 mediates TNF-induced cell death in mouse embryonic fibroblasts via regulation of both caspase and cathepsin protease pathways.

Recent studies strongly suggest an active involvement of the c-Jun N-terminal kinase (JNK) signaling pathway in tumor necrosis factor (TNF)-induced apoptosis. The direct evidence for the role of JNK and its isoforms has been missing and the mechanism of how JNK actually could facilitate this process...

Podrobná bibliografie
Hlavní autoři:	Dietrich, N, Thastrup, J, Holmberg, C, Gyrd-Hansen, M, Fehrenbacher, N, Lademann, U, Lerdrup, M, Herdegen, T, Jäättelä, M, Kallunki, T
Médium:	Journal article
Jazyk:	English
Vydáno:	2004

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