JNK2 mediates TNF-induced cell death in mouse embryonic fibroblasts via regulation of both caspase and cathepsin protease pathways.

JNK2 mediates TNF-induced cell death in mouse embryonic fibroblasts via regulation of both caspase and cathepsin protease pathways.

Recent studies strongly suggest an active involvement of the c-Jun N-terminal kinase (JNK) signaling pathway in tumor necrosis factor (TNF)-induced apoptosis. The direct evidence for the role of JNK and its isoforms has been missing and the mechanism of how JNK actually could facilitate this process...

Full beskrivning

Bibliografiska uppgifter
Huvudupphovsmän:	Dietrich, N, Thastrup, J, Holmberg, C, Gyrd-Hansen, M, Fehrenbacher, N, Lademann, U, Lerdrup, M, Herdegen, T, Jäättelä, M, Kallunki, T
Materialtyp:	Journal article
Språk:	English
Publicerad:	2004

Liknande verk

Diarylurea compounds inhibit caspase activation by preventing the formation of the active 700-kilodalton apoptosome complex.
av: Lademann, U, et al.
Publicerad: (2003)

Apoptosome-independent activation of the lysosomal cell death pathway by caspase-9.
av: Gyrd-Hansen, M, et al.
Publicerad: (2006)

Sensitization to the lysosomal cell death pathway upon immortalization and transformation.
av: Fehrenbacher, N, et al.
Publicerad: (2004)

Heat shock protein 70 promotes cell survival by inhibiting lysosomal membrane permeabilization.
av: Nylandsted, J, et al.
Publicerad: (2004)

Retrovirus Entry by Endocytosis and Cathepsin Proteases
av: Yoshinao Kubo, et al.
Publicerad: (2012-01-01)

Plant cathepsin B, a versatile protease
av: Marianna Coppola, et al.
Publicerad: (2024-02-01)

Inhibition of the Plasma-Membrane Associated Serine Protease Cathepsin G by Mycobacterium tuberculosis Rv3364c Suppresses Caspase-1 and Pyroptosis in Macrophages
av: Lia eDanelishvili, et al.
Publicerad: (2012-01-01)

Cathepsin proteases mediate photoreceptor cell degeneration in Drosophila
av: Ronald D. Kinser, et al.
Publicerad: (2012-06-01)

Cathepsin F of is a recently evolved cysteine protease
av: Sarah Sloan, et al.
Publicerad: (2020-10-01)

The Multifaceted Role of the Lysosomal Protease Cathepsins in Kidney Disease
av: Pasquale Cocchiaro, et al.
Publicerad: (2017-12-01)

IAPs: from caspase inhibitors to modulators of NF-kappaB, inflammation and cancer.
av: Gyrd-Hansen, M, et al.
Publicerad: (2010)

Human brain gene expression profiles of the cathepsin V and cathepsin L cysteine proteases, with the PC1/3 and PC2 serine proteases, involved in neuropeptide production
av: Sonia Podvin, et al.
Publicerad: (2018-07-01)

Involvement of JNK and Caspase Activation in Hoiamide A-Induced Neurotoxicity in Neocortical Neurons
av: Zhengyu Cao, et al.
Publicerad: (2015-02-01)

Heat shock protein 70 promotes cancer cell viability by safeguarding lysosomal integrity.
av: Gyrd-Hansen, M, et al.
Publicerad: (2004)

Cathepsin F cysteine protease of the human liver fluke, Opisthorchis viverrini.
av: Porntip Pinlaor, et al.
Publicerad: (2009-01-01)

Molecular characterization of a cathepsin F-like protease in Trichinella spiralis
av: Zi-gang Qu, et al.
Publicerad: (2015-12-01)

Identification and characterization of Clonorchis sinensis cathepsin B proteases in the pathogenesis of clonorchiasis
av: Wenjun Chen, et al.
Publicerad: (2015-12-01)

TNF-α contributes to sarcopenia through caspase-8/caspase-3/GSDME-mediated pyroptosis
av: Jingying Wu, et al.
Publicerad: (2023-02-01)

JNK-dependent modulation of the protease secretome profile of osteoarthritic cartilage
av: Ismail, H, et al.
Publicerad: (2018)

Caspase-1 and Cathepsin B Inhibitors from Marine Invertebrates, Aiming at a Reduction in Neuroinflammation
av: Rafaela Indalecio Moreno, et al.
Publicerad: (2022-09-01)

Thymoquinone inhibits autophagy and induces cathepsin-mediated, caspase-independent cell death in glioblastoma cells.
av: Ira O Racoma, et al.
Publicerad: (2013-01-01)

Lysosomes and Nonapoptotic Pathways
av: Kirkegaard-Sørensen, T, et al.
Publicerad: (2008)

The importance of pH in regulating the function of the Fasciola hepatica cathepsin L1 cysteine protease.
av: Jonathan Lowther, et al.
Publicerad: (2009-01-01)

ERK2 and JNK1 contribute to TNF-α-induced IL-8 expression in synovial fibroblasts.
av: Shinichi Namba, et al.
Publicerad: (2017-01-01)

Enhanced antigen cross-presentation in human colorectal cancer-associated fibroblasts through upregulation of the lysosomal protease cathepsin S
av: Peter A van Veelen, et al.
Publicerad: (2022-03-01)

Cathepsin B- and L-like Protease Activities Are Induced During Developmental Barley Leaf Senescence
av: Igor A. Schepetkin, et al.
Publicerad: (2024-10-01)

Cathepsin D: Analysis of its potential role as an amyloid beta degrading protease
av: Lisa Gallwitz, et al.
Publicerad: (2022-12-01)

TNF receptors regulate vascular homeostasis in zebrafish through a caspase-8, caspase-2 and P53 apoptotic program that bypasses caspase-3
av: Raquel Espín, et al.
Publicerad: (2013-03-01)

How to Choose the Right Inducible Gene Expression System for Mammalian Studies?
av: Tuula Kallunki, et al.
Publicerad: (2019-07-01)

Calcium Hydroxide Increases Human Umbilical Cord Mesenchymal Stem Cells Expressions of Apoptotic Protease-Activating Factor-1, Caspase-3 and Caspase-9
av: Prasetyo EP, et al.
Publicerad: (2021-03-01)

Tumor-promoting function of apoptotic caspases by an amplification loop involving ROS, macrophages and JNK in Drosophila
av: Ernesto Pérez, et al.
Publicerad: (2017-08-01)

Compartimentalization of TNF-receptor 1 signalling: acid sphingomyelinase is activated by Caspase-8 in internalized TNF-R1 receptosomes
av: Schütze S, et al.
Publicerad: (2009-02-01)

Dual Inhibition of HIV-1 and Cathepsin L Proteases by <i>Sarcandra glabra</i>
av: Bowen Pan, et al.
Publicerad: (2022-08-01)

Anionic Phospholipids Induce Conformational Changes in Phosphoenolpyruvate Carboxylase to Increase Sensitivity to Cathepsin Proteases
av: Jacinto Gandullo, et al.
Publicerad: (2019-05-01)

Correction: Expression Analysis of All Protease Genes Reveals Cathepsin K to Be Overexpressed in Glioblastoma.
av: Urška Verbovšek, et al.
Publicerad: (2015-01-01)

Erratum: IAPs: From caspase inhibitors to modulators of NF-κB, inflammation and cancer (Nature Reviews Cancer (2010) 10 (561-574))
av: Gyrd-Hansen, M, et al.
Publicerad: (2010)

Molecular characterization of EcCLP1, a new putative cathepsin L protease from Echinococcus canadensis
av: Naidich Ariel, et al.
Publicerad: (2024-01-01)

Discovery of Triple Inhibitors of Both SARS-CoV-2 Proteases and Human Cathepsin L
av: Ittipat Meewan, et al.
Publicerad: (2022-06-01)

Pharmacophore Virtual Screening Identifies Riboflavin as an Inhibitor of the Schistosome Cathepsin B1 Protease with Antiparasitic Activity
av: Ramon M. Cogo, et al.
Publicerad: (2024-05-01)

RIPK1 suppresses apoptosis mediated by TNF and caspase-3 in intervertebral discs
av: Xubin Qiu, et al.
Publicerad: (2019-04-01)