RECONsidering sensing of cyclic dinucleotides
Detection of cyclic dinucleotides (cdNs) by the STING pathway potently triggers the antiviral response. McFarland et al. now show that the mouse oxidoreductase RECON acts as a sensor for some bacterial cdNs, modulating innate signaling in a manner independent of STING to promote an antibacterial sta...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Cell Press
2017
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| _version_ | 1797069573369888768 |
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| author | Maelfait, J Rehwinkel, J |
| author_facet | Maelfait, J Rehwinkel, J |
| author_sort | Maelfait, J |
| collection | OXFORD |
| description | Detection of cyclic dinucleotides (cdNs) by the STING pathway potently triggers the antiviral response. McFarland et al. now show that the mouse oxidoreductase RECON acts as a sensor for some bacterial cdNs, modulating innate signaling in a manner independent of STING to promote an antibacterial state. |
| first_indexed | 2024-03-06T22:26:27Z |
| format | Journal article |
| id | oxford-uuid:56d07d04-6c8e-46ef-a267-763f5538362d |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:26:27Z |
| publishDate | 2017 |
| publisher | Cell Press |
| record_format | dspace |
| spelling | oxford-uuid:56d07d04-6c8e-46ef-a267-763f5538362d2022-03-26T16:52:50ZRECONsidering sensing of cyclic dinucleotidesJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:56d07d04-6c8e-46ef-a267-763f5538362dEnglishSymplectic Elements at OxfordCell Press2017Maelfait, JRehwinkel, JDetection of cyclic dinucleotides (cdNs) by the STING pathway potently triggers the antiviral response. McFarland et al. now show that the mouse oxidoreductase RECON acts as a sensor for some bacterial cdNs, modulating innate signaling in a manner independent of STING to promote an antibacterial state. |
| spellingShingle | Maelfait, J Rehwinkel, J RECONsidering sensing of cyclic dinucleotides |
| title | RECONsidering sensing of cyclic dinucleotides |
| title_full | RECONsidering sensing of cyclic dinucleotides |
| title_fullStr | RECONsidering sensing of cyclic dinucleotides |
| title_full_unstemmed | RECONsidering sensing of cyclic dinucleotides |
| title_short | RECONsidering sensing of cyclic dinucleotides |
| title_sort | reconsidering sensing of cyclic dinucleotides |
| work_keys_str_mv | AT maelfaitj reconsideringsensingofcyclicdinucleotides AT rehwinkelj reconsideringsensingofcyclicdinucleotides |