Mice over-expressing the myocardial creatine transporter develop progressive heart failure and show decreased glycolytic capacity.

Mice over-expressing the myocardial creatine transporter develop progressive heart failure and show decreased glycolytic capacity.

The metabolic phenotype of the failing heart includes a decrease in phosphocreatine and total creatine concentration [Cr], potentially contributing to contractile dysfunction. Surprisingly, in 32- week-old mice over-expressing the myocardial creatine transporter (CrT-OE), we previously demonstrated...

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Bibliographic Details
Main Authors:	Phillips, D, Ten Hove, M, Schneider, J, Wu, C, Sebag-Montefiore, L, Aponte, A, Lygate, C, Wallis, J, Clarke, K, Watkins, H, Balaban, R, Neubauer, S
Format:	Journal article
Language:	English
Published:	2010

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