A subset of HLA-I peptides are not genomically templated: Evidence for cis- and trans-spliced peptide ligands

The diversity of peptides displayed by class I human leukocyte antigen (HLA) plays an essential role in T cell immunity. The peptide repertoire is extended by various posttranslational modifications, including proteasomal splicing of peptide fragments from distinct regions of an antigen to form nong...

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Detalhes bibliográficos
Main Authors: Faridi, P, Li, C, Ramarathinam, S, Vivian, J, Illing, P, Mifsud, N, Ayala, R, Song, J, Gearing, L, Hertzog, P, Ternette, N, Rossjohn, J, Croft, N, Purcell, A
Formato: Journal article
Idioma:English
Publicado em: American Association for the Advancement of Science 2018