7-Deazaxanthine, a novel prototype inhibitor of thymidine phosphorylase.
7-Deazaxanthine (7DX) was identified as a novel inhibitor of thymidine (dThd) phosphorylase (TPase). It inhibited the TPase reaction in a concentration-dependent manner. At 1 mM, it almost completely prevented the TPase-catalysed hydrolysis of dThd to thymine. The 50% inhibitory concentration (IC50...
| Asıl Yazarlar: | , , , , , , , |
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| Materyal Türü: | Journal article |
| Dil: | English |
| Baskı/Yayın Bilgisi: |
1998
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| _version_ | 1826273353161244672 |
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| author | Balzarini, J Gamboa, A Esnouf, R Liekens, S Neyts, J De Clercq, E Camarasa, M Pérez-Pérez, M |
| author_facet | Balzarini, J Gamboa, A Esnouf, R Liekens, S Neyts, J De Clercq, E Camarasa, M Pérez-Pérez, M |
| author_sort | Balzarini, J |
| collection | OXFORD |
| description | 7-Deazaxanthine (7DX) was identified as a novel inhibitor of thymidine (dThd) phosphorylase (TPase). It inhibited the TPase reaction in a concentration-dependent manner. At 1 mM, it almost completely prevented the TPase-catalysed hydrolysis of dThd to thymine. The 50% inhibitory concentration (IC50 of 7DX was 40 microM in the presence of 100 microM of the natural substrate dThd. 7DX is also endowed with a marked inhibitory effect on angiogenesis. It significantly prevents neovascularisation in the chicken chorioallantoic membrane during development. 7DX is the first purine derivative shown to be a potent inhibitor of purified TPase and angiogenesis. |
| first_indexed | 2024-03-06T22:26:57Z |
| format | Journal article |
| id | oxford-uuid:56f4e9ae-edc1-410c-8531-501deaab58d9 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:26:57Z |
| publishDate | 1998 |
| record_format | dspace |
| spelling | oxford-uuid:56f4e9ae-edc1-410c-8531-501deaab58d92022-03-26T16:53:47Z7-Deazaxanthine, a novel prototype inhibitor of thymidine phosphorylase.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:56f4e9ae-edc1-410c-8531-501deaab58d9EnglishSymplectic Elements at Oxford1998Balzarini, JGamboa, AEsnouf, RLiekens, SNeyts, JDe Clercq, ECamarasa, MPérez-Pérez, M7-Deazaxanthine (7DX) was identified as a novel inhibitor of thymidine (dThd) phosphorylase (TPase). It inhibited the TPase reaction in a concentration-dependent manner. At 1 mM, it almost completely prevented the TPase-catalysed hydrolysis of dThd to thymine. The 50% inhibitory concentration (IC50 of 7DX was 40 microM in the presence of 100 microM of the natural substrate dThd. 7DX is also endowed with a marked inhibitory effect on angiogenesis. It significantly prevents neovascularisation in the chicken chorioallantoic membrane during development. 7DX is the first purine derivative shown to be a potent inhibitor of purified TPase and angiogenesis. |
| spellingShingle | Balzarini, J Gamboa, A Esnouf, R Liekens, S Neyts, J De Clercq, E Camarasa, M Pérez-Pérez, M 7-Deazaxanthine, a novel prototype inhibitor of thymidine phosphorylase. |
| title | 7-Deazaxanthine, a novel prototype inhibitor of thymidine phosphorylase. |
| title_full | 7-Deazaxanthine, a novel prototype inhibitor of thymidine phosphorylase. |
| title_fullStr | 7-Deazaxanthine, a novel prototype inhibitor of thymidine phosphorylase. |
| title_full_unstemmed | 7-Deazaxanthine, a novel prototype inhibitor of thymidine phosphorylase. |
| title_short | 7-Deazaxanthine, a novel prototype inhibitor of thymidine phosphorylase. |
| title_sort | 7 deazaxanthine a novel prototype inhibitor of thymidine phosphorylase |
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